{
  "url": "https://dantelabs.com/da/genes/slc34a2",
  "gene": {
    "slug": "slc34a2",
    "symbol": "SLC34A2",
    "name": "solute carrier family 34 member 2",
    "hgnc": "HGNC:11020",
    "summary": null,
    "location": "4p15.2",
    "locusType": "gene with protein product",
    "aliases": [
      "NAPI-3B",
      "NaPi-2b",
      "NPTIIb",
      "NaPi2b",
      "NAPI-IIb"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000157765",
    "entrezId": 10568,
    "omim": [
      "604217"
    ],
    "uniprot": [
      "O95436"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 25655851,
      "end": 25678748,
      "strand": "+",
      "ensemblTranscript": "ENST00000382051.8",
      "refseqTranscript": "NM_006424.3",
      "ensemblProtein": "ENSP00000371483.3",
      "refseqProtein": "NP_006415.3",
      "exons": [
        {
          "start": 25655851,
          "end": 25655890
        },
        {
          "start": 25662498,
          "end": 25662612
        },
        {
          "start": 25662705,
          "end": 25662842
        },
        {
          "start": 25664202,
          "end": 25664330
        },
        {
          "start": 25666128,
          "end": 25666271
        },
        {
          "start": 25667880,
          "end": 25667991
        },
        {
          "start": 25669647,
          "end": 25669842
        },
        {
          "start": 25670738,
          "end": 25670833
        },
        {
          "start": 25671601,
          "end": 25671721
        },
        {
          "start": 25673087,
          "end": 25673254
        },
        {
          "start": 25674296,
          "end": 25674412
        },
        {
          "start": 25674505,
          "end": 25674629
        },
        {
          "start": 25676135,
          "end": 25678748
        }
      ],
      "cds": {
        "start": 25662501,
        "end": 25676749
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 25656923,
      "end": 25680370,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 25167300,
      "end": 26167299,
      "genes": [
        {
          "symbol": "PI4K2B",
          "ensemblId": "ENSG00000038210",
          "biotype": "protein_coding",
          "start": 25160663,
          "end": 25280542,
          "strand": "+",
          "slug": "pi4k2b"
        },
        {
          "symbol": "ZCCHC4",
          "ensemblId": "ENSG00000168228",
          "biotype": "protein_coding",
          "start": 25312768,
          "end": 25372306,
          "strand": "+",
          "slug": "zcchc4"
        },
        {
          "symbol": "ANAPC4",
          "ensemblId": "ENSG00000053900",
          "biotype": "protein_coding",
          "start": 25377210,
          "end": 25420310,
          "strand": "+",
          "slug": "anapc4"
        },
        {
          "symbol": "SEL1L3",
          "ensemblId": "ENSG00000091490",
          "biotype": "protein_coding",
          "start": 25713965,
          "end": 25863760,
          "strand": "-",
          "slug": "sel1l3"
        },
        {
          "symbol": "SMIM20",
          "ensemblId": "ENSG00000250317",
          "biotype": "protein_coding",
          "start": 25861830,
          "end": 25931807,
          "strand": "+",
          "slug": "smim20"
        },
        {
          "symbol": "RBPJ",
          "ensemblId": "ENSG00000168214",
          "biotype": "protein_coding",
          "start": 26163455,
          "end": 26435131,
          "strand": "+",
          "slug": "rbpj"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "pulmonary-alveolar-microlithiasis",
        "name": "Pulmonær alveolær mikrolithiasis",
        "diseases": [
          {
            "mondoId": "MONDO:0009928",
            "name": "Pulmonær alveolær mikrolithiasis",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Gradvis ophobning af mikroskopiske calciumphosphataflejringer i alveolerne, forårsaget af tab af phosphattransportøren SLC34A2. Den kan give ingen symptomer i årevis, før lungefunktionen forringes.",
            "management": "At kende din status kan støtte en tidligere diagnose, regelmæssig overvågning af lungefunktionen og, for bærere, information til familieplanlægning.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/pulmonary-alveolar-microlithiasis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-circulating-calcium-concentration",
        "name": "Abnormal blood calcium levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/abnormal-circulating-calcium-concentration"
      },
      {
        "slug": "abnormal-circulating-phosphate-ion-concentration",
        "name": "Abnormal circulating phosphate ion concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/abnormal-circulating-phosphate-ion-concentration"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "cyanosis",
        "name": "Blue discoloration of the skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cyanosis"
      },
      {
        "slug": "dyspnea",
        "name": "Breathing difficulty",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dyspnea"
      },
      {
        "slug": "bronchitis",
        "name": "Bronchitis",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/bronchitis"
      },
      {
        "slug": "calcification-of-the-aorta",
        "name": "Calcification of the aorta",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/calcification-of-the-aorta"
      },
      {
        "slug": "calcium-nephrolithiasis",
        "name": "Calcium kidney stone",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/calcium-nephrolithiasis"
      },
      {
        "slug": "chest-pain",
        "name": "Chest pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chest-pain"
      },
      {
        "slug": "clubbing-of-fingers",
        "name": "Clubbing of fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/clubbing-of-fingers"
      },
      {
        "slug": "pneumothorax",
        "name": "Collapsed lung",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pneumothorax"
      },
      {
        "slug": "hemoptysis",
        "name": "Coughing up blood",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hemoptysis"
      },
      {
        "slug": "decreased-fertility",
        "name": "Decreased fertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/decreased-fertility"
      },
      {
        "slug": "nonproductive-cough",
        "name": "Dry cough",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nonproductive-cough"
      },
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      },
      {
        "slug": "elevated-circulating-surfactant-protein-concentration",
        "name": "Elevated circulating surfactant protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-surfactant-protein-concentration"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "exertional-dyspnea",
        "name": "Exertional breathlessness",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/exertional-dyspnea"
      },
      {
        "slug": "fatigable-weakness",
        "name": "Fatigable weakness",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fatigable-weakness"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "gonadal-calcification",
        "name": "Gonadal calcification",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/gonadal-calcification"
      },
      {
        "slug": "ground-glass-opacification",
        "name": "Ground-glass opacification",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/ground-glass-opacification"
      },
      {
        "slug": "increased-pulmonary-vascular-resistance",
        "name": "Increased pulmonary vascular resistance",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-pulmonary-vascular-resistance"
      },
      {
        "slug": "tachypnea",
        "name": "Increased respiratory rate or depth of breathing",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/tachypnea"
      },
      {
        "slug": "interlobular-septal-thickening",
        "name": "Interlobular septal thickening",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/interlobular-septal-thickening"
      },
      {
        "slug": "intraalveolar-nodular-calcifications",
        "name": "Intraalveolar nodular calcifications",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/intraalveolar-nodular-calcifications"
      },
      {
        "slug": "hypoxemia",
        "name": "Low blood oxygen level",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypoxemia"
      },
      {
        "slug": "pulmonary-infiltrates",
        "name": "Lung infiltrates",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pulmonary-infiltrates"
      },
      {
        "slug": "mitral-valve-calcification",
        "name": "Mitral valve calcification",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/mitral-valve-calcification"
      },
      {
        "slug": "oxygen-desaturation-on-exertion",
        "name": "Oxygen desaturation on exertion",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oxygen-desaturation-on-exertion"
      },
      {
        "slug": "peripheral-edema",
        "name": "Peripheral edema",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/peripheral-edema"
      },
      {
        "slug": "bronchiectasis",
        "name": "Permanent enlargement of the airways of the lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bronchiectasis"
      },
      {
        "slug": "pleural-thickening",
        "name": "Pleural thickening",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pleural-thickening"
      },
      {
        "slug": "progressive-pulmonary-function-impairment",
        "name": "Progressive pulmonary function impairment",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/progressive-pulmonary-function-impairment"
      },
      {
        "slug": "pulmonary-fibrosis",
        "name": "Pulmonary scarring",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/pulmonary-fibrosis"
      },
      {
        "slug": "respiratory-failure",
        "name": "Respiratory failure",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/respiratory-failure"
      },
      {
        "slug": "respiratory-insufficiency",
        "name": "Respiratory function loss",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/respiratory-insufficiency"
      },
      {
        "slug": "respiratory-tract-infection",
        "name": "Respiratory tract infection",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/respiratory-tract-infection"
      },
      {
        "slug": "right-ventricular-failure",
        "name": "Right ventricular failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/right-ventricular-failure"
      },
      {
        "slug": "restrictive-ventilatory-defect",
        "name": "Stiff lung or chest wall causing decreased lung volume",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/restrictive-ventilatory-defect"
      },
      {
        "slug": "stippled-calcification-in-carpal-bones",
        "name": "Stippled calcification in carpal bones",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/stippled-calcification-in-carpal-bones"
      },
      {
        "slug": "subpleural-interstitial-thickening",
        "name": "Subpleural interstitial thickening",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/subpleural-interstitial-thickening"
      },
      {
        "slug": "testicular-microlithiasis",
        "name": "Testicular microlithiasis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/testicular-microlithiasis"
      },
      {
        "slug": "weight-loss",
        "name": "Weight loss",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/weight-loss"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}