{
  "url": "https://dantelabs.com/da/genes/fshb",
  "gene": {
    "slug": "fshb",
    "symbol": "FSHB",
    "name": "follicle stimulating hormone subunit beta",
    "hgnc": "HGNC:3964",
    "summary": null,
    "location": "11p14.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [],
    "ensemblId": "ENSG00000131808",
    "entrezId": 2488,
    "omim": [
      "136530"
    ],
    "uniprot": [
      "P01225"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 30231014,
      "end": 30235194,
      "strand": "+",
      "ensemblTranscript": "ENST00000533718.2",
      "refseqTranscript": "NM_001382289.1",
      "ensemblProtein": "ENSP00000433424.1",
      "refseqProtein": "NP_001369218.1",
      "exons": [
        {
          "start": 30231014,
          "end": 30231048
        },
        {
          "start": 30231866,
          "end": 30232061
        },
        {
          "start": 30233570,
          "end": 30235194
        }
      ],
      "cds": {
        "start": 30231903,
        "end": 30233800
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 30252563,
      "end": 30256808,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 29733104,
      "end": 30733103,
      "genes": [
        {
          "symbol": "KCNA4",
          "ensemblId": "ENSG00000182255",
          "biotype": "protein_coding",
          "start": 30008122,
          "end": 30017043,
          "strand": "-",
          "slug": "kcna4"
        },
        {
          "symbol": "ARL14EP",
          "ensemblId": "ENSG00000152219",
          "biotype": "protein_coding",
          "start": 30323049,
          "end": 30338967,
          "strand": "+",
          "slug": "arl14ep"
        },
        {
          "symbol": "MPPED2",
          "ensemblId": "ENSG00000066382",
          "biotype": "protein_coding",
          "start": 30384493,
          "end": 30586927,
          "strand": "-",
          "slug": "mpped2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hypogonadotropic-hypogonadism",
        "name": "Hypogonadotrop hypogonadisme",
        "diseases": [
          {
            "mondoId": "MONDO:0018555",
            "name": "Hypogonadotrop hypogonadisme",
            "genes": 49,
            "inheritance": null,
            "description": "Unormal funktion af æggestokke eller testikler på grund af utilstrækkelig hormonel stimulation fra hypothalamus-hypofyse-aksen.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/hypogonadotropic-hypogonadism"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-sperm-morphology",
        "name": "Abnormal shape of sperm",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormal-sperm-morphology"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "hypogonadism",
        "name": "Decreased activity of gonads",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hypogonadism"
      },
      {
        "slug": "decreased-circulating-follicle-stimulating-hormone-concentration",
        "name": "Decreased circulating follicle stimulating hormone concentration",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-follicle-stimulating-hormone-concentration"
      },
      {
        "slug": "decreased-female-libido",
        "name": "Decreased female sex drive",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-female-libido"
      },
      {
        "slug": "male-hypogonadism",
        "name": "Decreased function of male gonad",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-hypogonadism"
      },
      {
        "slug": "decreased-muscle-mass",
        "name": "Decreased muscle mass",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/decreased-muscle-mass"
      },
      {
        "slug": "decreased-serum-estradiol",
        "name": "Decreased serum estradiol",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-serum-estradiol"
      },
      {
        "slug": "decreased-serum-testosterone-concentration",
        "name": "Decreased serum testosterone level",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-serum-testosterone-concentration"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "delayed-skeletal-maturation",
        "name": "Delayed bone maturation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-skeletal-maturation"
      },
      {
        "slug": "delayed-puberty",
        "name": "Delayed puberty",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-puberty"
      },
      {
        "slug": "delayed-menarche",
        "name": "Delayed start of first period",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system",
          "growth-abnormality"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/delayed-menarche"
      },
      {
        "slug": "elevated-circulating-luteinizing-hormone-level",
        "name": "Elevated circulating luteinizing hormone level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-luteinizing-hormone-level"
      },
      {
        "slug": "female-hypogonadism",
        "name": "Female hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/female-hypogonadism"
      },
      {
        "slug": "gonadotropin-deficiency",
        "name": "Gonadotropin deficiency",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/gonadotropin-deficiency"
      },
      {
        "slug": "hyperplasia-of-the-leydig-cells",
        "name": "Hyperplasia of the Leydig cells",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hyperplasia-of-the-leydig-cells"
      },
      {
        "slug": "hypogonadotropic-hypogonadism",
        "name": "Hypogonadotropic hypogonadism",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypogonadotropic-hypogonadism"
      },
      {
        "slug": "infertility",
        "name": "Infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/infertility"
      },
      {
        "slug": "oligomenorrhea",
        "name": "Light or infrequent menstrual periods",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oligomenorrhea"
      },
      {
        "slug": "sparse-axillary-hair",
        "name": "Limited armpit hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-axillary-hair"
      },
      {
        "slug": "anosmia",
        "name": "Lost smell",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/anosmia"
      },
      {
        "slug": "oligozoospermia",
        "name": "Low sperm count",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/oligozoospermia"
      },
      {
        "slug": "primary-amenorrhea",
        "name": "Primary amenorrhea",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/primary-amenorrhea"
      },
      {
        "slug": "sparse-pubic-hair",
        "name": "Sparse pubic hair",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/sparse-pubic-hair"
      },
      {
        "slug": "testicular-atrophy",
        "name": "Testicular degeneration",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/testicular-atrophy"
      },
      {
        "slug": "bilateral-breast-hypoplasia",
        "name": "Two underdeveloped breasts",
        "systems": [
          "abnormality-of-the-breast"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/bilateral-breast-hypoplasia"
      }
    ],
    "related": [
      {
        "slug": "anos1",
        "symbol": "ANOS1",
        "name": "anosmin 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/anos1"
      },
      {
        "slug": "arhgap35",
        "symbol": "ARHGAP35",
        "name": "Rho GTPase activating protein 35",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/arhgap35"
      },
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "name": "chromodomain helicase DNA binding protein 7",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/chd7"
      },
      {
        "slug": "cpe",
        "symbol": "CPE",
        "name": "carboxypeptidase E",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/cpe"
      },
      {
        "slug": "dcaf17",
        "symbol": "DCAF17",
        "name": "DDB1 and CUL4 associated factor 17",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/dcaf17"
      },
      {
        "slug": "fezf1",
        "symbol": "FEZF1",
        "name": "FEZ family zinc finger 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fezf1"
      },
      {
        "slug": "fgf17",
        "symbol": "FGF17",
        "name": "fibroblast growth factor 17",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fgf17"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "name": "fibroblast growth factor 8",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "name": "fibroblast growth factor receptor 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fgfr1"
      },
      {
        "slug": "foxa2",
        "symbol": "FOXA2",
        "name": "forkhead box A2",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/foxa2"
      },
      {
        "slug": "gh1",
        "symbol": "GH1",
        "name": "growth hormone 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/gh1"
      },
      {
        "slug": "ghrhr",
        "symbol": "GHRHR",
        "name": "growth hormone releasing hormone receptor",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/ghrhr"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}