{
  "url": "https://dantelabs.com/da/genes/dspp",
  "gene": {
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    "symbol": "DSPP",
    "name": "dentin sialophosphoprotein",
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    "summary": null,
    "location": "4q22.1",
    "locusType": "gene with protein product",
    "aliases": [
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      "DFNA39",
      "DGI1"
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    "entrezId": 1834,
    "omim": [
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    "uniprot": [
      "Q9NZW4"
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      "chrom": "4",
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      "ensemblTranscript": "ENST00000651931.1",
      "refseqTranscript": "NM_014208.3",
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      "refseqProtein": "NP_055023.2",
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    },
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        {
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        {
          "symbol": "HSD17B13",
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        {
          "symbol": "HSD17B11",
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          "biotype": "protein_coding",
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        {
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        },
        {
          "symbol": "SCPPPQ1",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "SPARCL1",
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          "strand": "-",
          "slug": "sparcl1"
        },
        {
          "symbol": "DMP1",
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          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "dmp1"
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        {
          "symbol": "IBSP",
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          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "MEPE",
          "ensemblId": "ENSG00000152595",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "SPP1",
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        {
          "symbol": "PKD2",
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        },
        {
          "symbol": "ABCG2",
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          "strand": "-",
          "slug": "abcg2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "dentinogenesis-imperfecta",
        "name": "Dentinogenesis imperfecta",
        "diseases": [
          {
            "mondoId": "MONDO:0018849",
            "name": "Dentinogenesis imperfecta",
            "genes": 1,
            "inheritance": "autosomal-dominant",
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "G2P",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/dentinogenesis-imperfecta"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "anterior-open-bite-malocclusion",
        "name": "Absence of overlap of anterior upper and lower teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/anterior-open-bite-malocclusion"
      },
      {
        "slug": "bilateral-sensorineural-hearing-impairment",
        "name": "Bilateral sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/bilateral-sensorineural-hearing-impairment"
      },
      {
        "slug": "periapical-bone-loss",
        "name": "Bone loss around tooth root",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/periapical-bone-loss"
      },
      {
        "slug": "dental-enamel-pits",
        "name": "Dental enamel pits",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/dental-enamel-pits"
      },
      {
        "slug": "dentinogenesis-imperfecta",
        "name": "Dentinogenesis imperfecta",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/dentinogenesis-imperfecta"
      },
      {
        "slug": "dentinogenesis-imperfecta-limited-to-primary-teeth",
        "name": "Dentinogenesis imperfecta limited to primary teeth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/dentinogenesis-imperfecta-limited-to-primary-teeth"
      },
      {
        "slug": "high-frequency-hearing-impairment",
        "name": "Hearing loss, high-frequency",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/high-frequency-hearing-impairment"
      },
      {
        "slug": "odontodysplasia",
        "name": "Odontodysplasia",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/odontodysplasia"
      },
      {
        "slug": "pulp-calcification",
        "name": "Pulp stones",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/pulp-calcification"
      },
      {
        "slug": "tinnitus",
        "name": "Ringing in ears",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/tinnitus"
      },
      {
        "slug": "thistle-tube-shaped-pulp",
        "name": "Thistle tube shaped pulp",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/thistle-tube-shaped-pulp"
      },
      {
        "slug": "yellow-brown-discoloration-of-the-teeth",
        "name": "Yellow-brown discoloration of the teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/yellow-brown-discoloration-of-the-teeth"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}