{
  "url": "https://dantelabs.com/da/genes/cblb",
  "gene": {
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    "symbol": "CBLB",
    "name": "Cbl proto-oncogene B",
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    "uniprot": [
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    "grch37": {
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      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
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          "ensemblId": "ENSG00000170017",
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      ],
      "truncated": false
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    "reports": [
      {
        "slug": "autoimmune-disease",
        "name": "Autoimmun sygdom",
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          {
            "mondoId": "MONDO:0007179",
            "name": "Autoimmun sygdom",
            "genes": 20,
            "inheritance": null,
            "description": "En lidelse, der skyldes tab af funktion eller vævsnedbrydning i et organ eller flere organer, og som opstår ved humorale eller cellulære immunreaktioner hos det enkelte individ mod egne vævsbestanddele. Den kan være systemisk (f.eks. systemisk lupus erythematosus) eller organspecifik (f.eks. thyreoiditis).",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
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            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/da/conditions/autoimmune-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "autoimmune-hemolytic-anemia",
        "name": "Autoimmune hemolytic anemia",
        "systems": [
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          "abnormality-of-the-immune-system"
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autoimmune-hemolytic-anemia"
      },
      {
        "slug": "vitiligo",
        "name": "Blotchy loss of skin color",
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vitiligo"
      },
      {
        "slug": "decreased-circulating-iga-concentration",
        "name": "Decreased circulating IgA concentration",
        "systems": [
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          "abnormality-of-the-immune-system"
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-iga-concentration"
      },
      {
        "slug": "decreased-circulating-igg-concentration",
        "name": "Decreased circulating IgG concentration",
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          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-igg-concentration"
      },
      {
        "slug": "decreased-circulating-igm-concentration",
        "name": "Decreased circulating IgM concentration",
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          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/decreased-circulating-igm-concentration"
      },
      {
        "slug": "decreased-circulating-specific-pneumococcal-antibody-concentration",
        "name": "Decreased circulating specific pneumococcal antibody concentration",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-specific-pneumococcal-antibody-concentration"
      },
      {
        "slug": "recurrent-fever",
        "name": "Episodic fever",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-fever"
      },
      {
        "slug": "hepatic-hemophagocytosis",
        "name": "Hepatic hemophagocytosis",
        "systems": [
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          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hepatic-hemophagocytosis"
      },
      {
        "slug": "urticaria",
        "name": "Hives",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/urticaria"
      },
      {
        "slug": "increased-circulating-interleukin-10-concentration",
        "name": "Increased circulating interleukin 10 concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-10-concentration"
      },
      {
        "slug": "increased-circulating-interleukin-6-concentration",
        "name": "Increased circulating interleukin 6 concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-6-concentration"
      },
      {
        "slug": "partial-absence-of-specific-antibody-response-to-tetanus-vaccine",
        "name": "Partial absence of specific antibody response to tetanus vaccine",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/partial-absence-of-specific-antibody-response-to-tetanus-vaccine"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      },
      {
        "slug": "type-i-diabetes-mellitus",
        "name": "Type 1 diabetes",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/type-i-diabetes-mellitus"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "related": [
      {
        "slug": "aire",
        "symbol": "AIRE",
        "name": "autoimmune regulator",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/aire"
      },
      {
        "slug": "atp2c1",
        "symbol": "ATP2C1",
        "name": "ATPase secretory pathway Ca2+ transporting 1",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/atp2c1"
      },
      {
        "slug": "c1qa",
        "symbol": "C1QA",
        "name": "complement C1q A chain",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/c1qa"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "name": "caspase 10",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/casp10"
      },
      {
        "slug": "casp8",
        "symbol": "CASP8",
        "name": "caspase 8",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/casp8"
      },
      {
        "slug": "chrng",
        "symbol": "CHRNG",
        "name": "cholinergic receptor nicotinic gamma subunit",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/chrng"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/ctla4"
      },
      {
        "slug": "dnase1l3",
        "symbol": "DNASE1L3",
        "name": "deoxyribonuclease 1L3",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/dnase1l3"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "name": "Fas cell surface death receptor",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "name": "Fas ligand",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/faslg"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "name": "forkhead box P3",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/foxp3"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "name": "KRas proto-oncogene, GTPase",
        "shared": 1,
        "url": "https://dantelabs.com/da/genes/kras"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}