{
  "url": "https://dantelabs.com/traits/transient-hyperphenylalaninemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "transient-hyperphenylalaninemia",
    "id": "HP:0008297",
    "name": "Transient hyperphenylalaninemia",
    "definition": "A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-phenylalanine-concentration",
        "name": "Abnormal circulating phenylalanine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-phenylalanine-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gch1",
        "symbol": "GCH1",
        "hgnc": "HGNC:4193",
        "name": "GTP cyclohydrolase 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gch1"
      },
      {
        "slug": "impdh2",
        "symbol": "IMPDH2",
        "hgnc": "HGNC:6053",
        "name": "inosine monophosphate dehydrogenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/impdh2"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "pcbd1",
        "symbol": "PCBD1",
        "hgnc": "HGNC:8646",
        "name": "pterin-4 alpha-carbinolamine dehydratase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcbd1"
      },
      {
        "slug": "spr",
        "symbol": "SPR",
        "hgnc": "HGNC:11257",
        "name": "sepiapterin reductase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spr"
      }
    ]
  }
}