{
  "url": "https://dantelabs.com/traits/thoracic-aorta-calcification",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "thoracic-aorta-calcification",
    "id": "HP:0004962",
    "name": "Thoracic aorta calcification",
    "definition": "An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "calcification-of-the-aorta",
        "name": "Calcification of the aorta",
        "url": "https://dantelabs.com/traits/calcification-of-the-aorta"
      }
    ],
    "narrower": [
      {
        "slug": "aortic-arch-calcification",
        "name": "Aortic arch calcification",
        "genes": 1,
        "url": "https://dantelabs.com/traits/aortic-arch-calcification"
      }
    ],
    "genes": [
      {
        "slug": "gata5",
        "symbol": "GATA5",
        "hgnc": "HGNC:15802",
        "name": "GATA binding protein 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata5"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "notch1",
        "symbol": "NOTCH1",
        "hgnc": "HGNC:7881",
        "name": "notch receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch1"
      },
      {
        "slug": "robo4",
        "symbol": "ROBO4",
        "hgnc": "HGNC:17985",
        "name": "roundabout guidance receptor 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo4"
      },
      {
        "slug": "smad6",
        "symbol": "SMAD6",
        "hgnc": "HGNC:6772",
        "name": "SMAD family member 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad6"
      }
    ]
  }
}