{
  "url": "https://dantelabs.com/traits/speech-apraxia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "speech-apraxia",
    "id": "HP:0011098",
    "name": "Speech apraxia",
    "definition": "A type of apraxia that is characterized by difficulty or inability to execute speech movements because of problems with coordination and motor problems, leading to incorrect articulation. An increase of errors with increasing word and phrase length may occur.",
    "synonyms": [
      "Apraxia of speech",
      "Verbal dyspraxia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "apraxia",
        "name": "Apraxia",
        "url": "https://dantelabs.com/traits/apraxia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "chd3",
        "symbol": "CHD3",
        "hgnc": "HGNC:1918",
        "name": "chromodomain helicase DNA binding protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd3"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "chd1",
        "symbol": "CHD1",
        "hgnc": "HGNC:1915",
        "name": "chromodomain helicase DNA binding protein 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chd1"
      },
      {
        "slug": "grin2a",
        "symbol": "GRIN2A",
        "hgnc": "HGNC:4585",
        "name": "glutamate ionotropic receptor NMDA type subunit 2A",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/grin2a"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "srpx2",
        "symbol": "SRPX2",
        "hgnc": "HGNC:30668",
        "name": "sushi repeat containing protein X-linked 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/srpx2"
      },
      {
        "slug": "dmpk",
        "symbol": "DMPK",
        "hgnc": "HGNC:2933",
        "name": "DM1 protein kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmpk"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "foxp1",
        "symbol": "FOXP1",
        "hgnc": "HGNC:3823",
        "name": "forkhead box P1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp1"
      },
      {
        "slug": "foxp2",
        "symbol": "FOXP2",
        "hgnc": "HGNC:13875",
        "name": "forkhead box P2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxp2"
      },
      {
        "slug": "kics2",
        "symbol": "KICS2",
        "hgnc": "HGNC:26517",
        "name": "KICSTOR subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kics2"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "rai1",
        "symbol": "RAI1",
        "hgnc": "HGNC:9834",
        "name": "retinoic acid induced 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rai1"
      },
      {
        "slug": "slc25a15",
        "symbol": "SLC25A15",
        "hgnc": "HGNC:10985",
        "name": "solute carrier family 25 member 15",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a15"
      },
      {
        "slug": "slc6a8",
        "symbol": "SLC6A8",
        "hgnc": "HGNC:11055",
        "name": "solute carrier family 6 member 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a8"
      },
      {
        "slug": "dlat",
        "symbol": "DLAT",
        "hgnc": "HGNC:2896",
        "name": "dihydrolipoamide S-acetyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlat"
      },
      {
        "slug": "galk1",
        "symbol": "GALK1",
        "hgnc": "HGNC:4118",
        "name": "galactokinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galk1"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "med13",
        "symbol": "MED13",
        "hgnc": "HGNC:22474",
        "name": "mediator complex subunit 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med13"
      },
      {
        "slug": "pou4f1",
        "symbol": "POU4F1",
        "hgnc": "HGNC:9218",
        "name": "POU class 4 homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou4f1"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "rnf135",
        "symbol": "RNF135",
        "hgnc": "HGNC:21158",
        "name": "ring finger protein 135",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf135"
      },
      {
        "slug": "sh2b1",
        "symbol": "SH2B1",
        "hgnc": "HGNC:30417",
        "name": "SH2B adaptor protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b1"
      },
      {
        "slug": "spart",
        "symbol": "SPART",
        "hgnc": "HGNC:18514",
        "name": "spartin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spart"
      },
      {
        "slug": "stub1",
        "symbol": "STUB1",
        "hgnc": "HGNC:11427",
        "name": "STIP1 homology and U-box containing protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stub1"
      },
      {
        "slug": "pacs1",
        "symbol": "PACS1",
        "hgnc": "HGNC:30032",
        "name": "phosphofurin acidic cluster sorting protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pacs1"
      },
      {
        "slug": "trappc11",
        "symbol": "TRAPPC11",
        "hgnc": "HGNC:25751",
        "name": "trafficking protein particle complex subunit 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc11"
      },
      {
        "slug": "usp7",
        "symbol": "USP7",
        "hgnc": "HGNC:12630",
        "name": "ubiquitin specific peptidase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp7"
      }
    ]
  }
}