{
  "url": "https://dantelabs.com/traits/spastic-ataxia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "spastic-ataxia",
    "id": "HP:0002497",
    "name": "Spastic ataxia",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "ataxia",
        "name": "Ataxia",
        "url": "https://dantelabs.com/traits/ataxia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "capn1",
        "symbol": "CAPN1",
        "hgnc": "HGNC:1476",
        "name": "calpain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/capn1"
      },
      {
        "slug": "mmadhc",
        "symbol": "MMADHC",
        "hgnc": "HGNC:25221",
        "name": "metabolism of cobalamin associated D",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mmadhc"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "hgnc": "HGNC:12407",
        "name": "tubulin alpha 4a",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba4a"
      },
      {
        "slug": "kif1c",
        "symbol": "KIF1C",
        "hgnc": "HGNC:6317",
        "name": "kinesin family member 1C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kif1c"
      },
      {
        "slug": "mars2",
        "symbol": "MARS2",
        "hgnc": "HGNC:25133",
        "name": "methionyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mars2"
      },
      {
        "slug": "tbce",
        "symbol": "TBCE",
        "hgnc": "HGNC:11582",
        "name": "tubulin folding cofactor E",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbce"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "dars2",
        "symbol": "DARS2",
        "hgnc": "HGNC:25538",
        "name": "aspartyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dars2"
      },
      {
        "slug": "gdap2",
        "symbol": "GDAP2",
        "hgnc": "HGNC:18010",
        "name": "ganglioside induced differentiation associated protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdap2"
      },
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "lrp4",
        "symbol": "LRP4",
        "hgnc": "HGNC:6696",
        "name": "LDL receptor related protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp4"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "tanc2",
        "symbol": "TANC2",
        "hgnc": "HGNC:30212",
        "name": "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tanc2"
      },
      {
        "slug": "tubb3",
        "symbol": "TUBB3",
        "hgnc": "HGNC:20772",
        "name": "tubulin beta 3 class III",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb3"
      },
      {
        "slug": "vamp1",
        "symbol": "VAMP1",
        "hgnc": "HGNC:12642",
        "name": "vesicle associated membrane protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vamp1"
      },
      {
        "slug": "afg3l2",
        "symbol": "AFG3L2",
        "hgnc": "HGNC:315",
        "name": "AFG3 like matrix AAA peptidase subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/afg3l2"
      },
      {
        "slug": "cacna1g",
        "symbol": "CACNA1G",
        "hgnc": "HGNC:1394",
        "name": "calcium voltage-gated channel subunit alpha1 G",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1g"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "mtpap",
        "symbol": "MTPAP",
        "hgnc": "HGNC:25532",
        "name": "mitochondrial poly(A) polymerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtpap"
      },
      {
        "slug": "prdm8",
        "symbol": "PRDM8",
        "hgnc": "HGNC:13993",
        "name": "PR/SET domain 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdm8"
      },
      {
        "slug": "sacs",
        "symbol": "SACS",
        "hgnc": "HGNC:10519",
        "name": "sacsin molecular chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sacs"
      }
    ]
  }
}