{
  "url": "https://dantelabs.com/traits/selective-tooth-agenesis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "selective-tooth-agenesis",
    "id": "HP:0001592",
    "name": "Absence of a tooth",
    "label": "Selective tooth agenesis",
    "definition": "Agenesis of some but not all teeth.",
    "synonyms": [
      "Missing a tooth",
      "Agenesis of a tooth",
      "Failure of development of a tooth"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "tooth-agenesis",
        "name": "Decreased number of teeth",
        "url": "https://dantelabs.com/traits/tooth-agenesis"
      }
    ],
    "narrower": [
      {
        "slug": "hypodontia",
        "name": "Failure of development of between one and six teeth",
        "genes": 242,
        "url": "https://dantelabs.com/traits/hypodontia"
      },
      {
        "slug": "oligodontia",
        "name": "Failure of development of more than six teeth",
        "genes": 70,
        "url": "https://dantelabs.com/traits/oligodontia"
      },
      {
        "slug": "agenesis-of-premolar",
        "name": "Absence of premolar",
        "genes": 15,
        "url": "https://dantelabs.com/traits/agenesis-of-premolar"
      },
      {
        "slug": "agenesis-of-incisor",
        "name": "Absence of front tooth",
        "genes": 4,
        "url": "https://dantelabs.com/traits/agenesis-of-incisor"
      },
      {
        "slug": "agenesis-of-molar",
        "name": "Absence of molar",
        "genes": 2,
        "url": "https://dantelabs.com/traits/agenesis-of-molar"
      },
      {
        "slug": "agenesis-of-canine",
        "name": "Absence of canine",
        "genes": 1,
        "url": "https://dantelabs.com/traits/agenesis-of-canine"
      }
    ],
    "genes": [
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      },
      {
        "slug": "cep152",
        "symbol": "CEP152",
        "hgnc": "HGNC:29298",
        "name": "centrosomal protein 152",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep152"
      },
      {
        "slug": "grem2",
        "symbol": "GREM2",
        "hgnc": "HGNC:17655",
        "name": "gremlin 2, DAN family BMP antagonist",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem2"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "hgnc": "HGNC:1762",
        "name": "cadherin 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdh3"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "eda",
        "symbol": "EDA",
        "hgnc": "HGNC:3157",
        "name": "ectodysplasin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eda"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tp63"
      }
    ]
  }
}