{
  "url": "https://dantelabs.com/traits/second-degree-atrioventricular-block",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "second-degree-atrioventricular-block",
    "id": "HP:0011706",
    "name": "Second degree atrioventricular block",
    "definition": "An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "atrioventricular-block",
        "name": "Interruption of electrical communication between upper and lower chambers of heart",
        "url": "https://dantelabs.com/traits/atrioventricular-block"
      }
    ],
    "narrower": [
      {
        "slug": "mobitz-i-atrioventricular-block",
        "name": "Mobitz I atrioventricular block",
        "genes": 5,
        "url": "https://dantelabs.com/traits/mobitz-i-atrioventricular-block"
      },
      {
        "slug": "2-1-atrioventricular-block",
        "name": "2:1 atrioventricular block",
        "genes": 3,
        "url": "https://dantelabs.com/traits/2-1-atrioventricular-block"
      }
    ],
    "genes": [
      {
        "slug": "calm3",
        "symbol": "CALM3",
        "hgnc": "HGNC:1449",
        "name": "calmodulin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calm3"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "popdc1",
        "symbol": "POPDC1",
        "hgnc": "HGNC:1152",
        "name": "popeye domain cAMP effector 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc1"
      },
      {
        "slug": "cacna1d",
        "symbol": "CACNA1D",
        "hgnc": "HGNC:1391",
        "name": "calcium voltage-gated channel subunit alpha1 D",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1d"
      },
      {
        "slug": "lamp2",
        "symbol": "LAMP2",
        "hgnc": "HGNC:6501",
        "name": "lysosome associated membrane protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamp2"
      },
      {
        "slug": "popdc2",
        "symbol": "POPDC2",
        "hgnc": "HGNC:17648",
        "name": "popeye domain cAMP effector 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/popdc2"
      },
      {
        "slug": "vezf1",
        "symbol": "VEZF1",
        "hgnc": "HGNC:12949",
        "name": "vascular endothelial zinc finger 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vezf1"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "cacna1s",
        "symbol": "CACNA1S",
        "hgnc": "HGNC:1397",
        "name": "calcium voltage-gated channel subunit alpha1 S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1s"
      },
      {
        "slug": "cdc45",
        "symbol": "CDC45",
        "hgnc": "HGNC:1739",
        "name": "cell division cycle 45",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc45"
      },
      {
        "slug": "gabra3",
        "symbol": "GABRA3",
        "hgnc": "HGNC:4077",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra3"
      },
      {
        "slug": "kcnj18",
        "symbol": "KCNJ18",
        "hgnc": "HGNC:39080",
        "name": "potassium inwardly rectifying channel subfamily J member 18",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj18"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      }
    ]
  }
}