{
  "url": "https://dantelabs.com/traits/reduced-factor-xii-activity",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "reduced-factor-xii-activity",
    "id": "HP:0004841",
    "name": "Reduced factor XII activity",
    "definition": "Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade.",
    "synonyms": [
      "Factor XII deficiency",
      "Hageman factor deficiency"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-intrinsic-pathway",
        "name": "Abnormality of the intrinsic pathway",
        "url": "https://dantelabs.com/traits/abnormality-of-the-intrinsic-pathway"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "f12",
        "symbol": "F12",
        "hgnc": "HGNC:3530",
        "name": "coagulation factor XII",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/f12"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "hgnc": "HGNC:6840",
        "name": "mitogen-activated protein kinase kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k1"
      },
      {
        "slug": "mgat2",
        "symbol": "MGAT2",
        "hgnc": "HGNC:7045",
        "name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mgat2"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "hgnc": "HGNC:9644",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn11"
      }
    ]
  }
}