{
  "url": "https://dantelabs.com/traits/recurrent-oral-thrush",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "recurrent-oral-thrush",
    "id": "HP:0009098",
    "name": "Chronic oral thrush",
    "label": "Recurrent oral thrush",
    "definition": "Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx.",
    "synonyms": [
      "Chronic oral candidiasis",
      "Persistent oral thrush"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "recurrent-mucocutaneous-candidiasis",
        "name": "Recurrent mucocutaneous candidiasis",
        "url": "https://dantelabs.com/traits/recurrent-mucocutaneous-candidiasis"
      },
      {
        "slug": "unusual-oral-thrush",
        "name": "Unusual oral thrush",
        "url": "https://dantelabs.com/traits/unusual-oral-thrush"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "ap3b1",
        "symbol": "AP3B1",
        "hgnc": "HGNC:566",
        "name": "adaptor related protein complex 3 subunit beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap3b1"
      },
      {
        "slug": "cd3g",
        "symbol": "CD3G",
        "hgnc": "HGNC:1675",
        "name": "CD3 gamma subunit of T-cell receptor complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3g"
      },
      {
        "slug": "coro1a",
        "symbol": "CORO1A",
        "hgnc": "HGNC:2252",
        "name": "coronin 1A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coro1a"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "ikbkb",
        "symbol": "IKBKB",
        "hgnc": "HGNC:5960",
        "name": "inhibitor of nuclear factor kappa B kinase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkb"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "lck",
        "symbol": "LCK",
        "hgnc": "HGNC:6524",
        "name": "LCK proto-oncogene, Src family tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lck"
      },
      {
        "slug": "man2b2",
        "symbol": "MAN2B2",
        "hgnc": "HGNC:29623",
        "name": "mannosidase alpha class 2B member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b2"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "trac",
        "symbol": "TRAC",
        "hgnc": "HGNC:12029",
        "name": "T cell receptor alpha constant",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trac"
      },
      {
        "slug": "traf3ip2",
        "symbol": "TRAF3IP2",
        "hgnc": "HGNC:1343",
        "name": "TRAF3 interacting protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3ip2"
      },
      {
        "slug": "il17ra",
        "symbol": "IL17RA",
        "hgnc": "HGNC:5985",
        "name": "interleukin 17 receptor A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il17ra"
      },
      {
        "slug": "card9",
        "symbol": "CARD9",
        "hgnc": "HGNC:16391",
        "name": "caspase recruitment domain family member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card9"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "jak3",
        "symbol": "JAK3",
        "hgnc": "HGNC:6193",
        "name": "Janus kinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jak3"
      },
      {
        "slug": "knstrn",
        "symbol": "KNSTRN",
        "hgnc": "HGNC:30767",
        "name": "kinetochore localized astrin (SPAG5) binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/knstrn"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "rorc",
        "symbol": "RORC",
        "hgnc": "HGNC:10260",
        "name": "RAR related orphan receptor C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rorc"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "zap70",
        "symbol": "ZAP70",
        "hgnc": "HGNC:12858",
        "name": "zeta chain of T cell receptor associated protein kinase 70",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zap70"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "cd3d",
        "symbol": "CD3D",
        "hgnc": "HGNC:1673",
        "name": "CD3 delta subunit of T-cell receptor complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3d"
      },
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "hgnc": "HGNC:1674",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3e"
      },
      {
        "slug": "cd40lg",
        "symbol": "CD40LG",
        "hgnc": "HGNC:11935",
        "name": "CD40 ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40lg"
      },
      {
        "slug": "dock2",
        "symbol": "DOCK2",
        "hgnc": "HGNC:2988",
        "name": "dedicator of cytokinesis 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock2"
      },
      {
        "slug": "foxn1",
        "symbol": "FOXN1",
        "hgnc": "HGNC:12765",
        "name": "forkhead box N1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxn1"
      },
      {
        "slug": "mvk",
        "symbol": "MVK",
        "hgnc": "HGNC:7530",
        "name": "mevalonate kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvk"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf2"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "tfrc",
        "symbol": "TFRC",
        "hgnc": "HGNC:11763",
        "name": "transferrin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfrc"
      },
      {
        "slug": "tlr8",
        "symbol": "TLR8",
        "hgnc": "HGNC:15632",
        "name": "toll like receptor 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr8"
      },
      {
        "slug": "wdr1",
        "symbol": "WDR1",
        "hgnc": "HGNC:12754",
        "name": "WD repeat domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr1"
      },
      {
        "slug": "znf341",
        "symbol": "ZNF341",
        "hgnc": "HGNC:15992",
        "name": "zinc finger protein 341",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf341"
      }
    ]
  }
}