{
  "url": "https://dantelabs.com/traits/prostate-cancer",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "prostate-cancer",
    "id": "HP:0012125",
    "name": "Prostate cancer",
    "definition": "A cancer of the prostate.",
    "synonyms": [
      "Prostatic cancer"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "prostate-neoplasm",
        "name": "Prostate neoplasm",
        "url": "https://dantelabs.com/traits/prostate-neoplasm"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "rnasel",
        "symbol": "RNASEL",
        "hgnc": "HGNC:10050",
        "name": "ribonuclease L",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnasel"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "bard1",
        "symbol": "BARD1",
        "hgnc": "HGNC:952",
        "name": "BRCA1 associated RING domain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bard1"
      },
      {
        "slug": "brca1",
        "symbol": "BRCA1",
        "hgnc": "HGNC:1100",
        "name": "BRCA1 DNA repair associated",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca1"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "brip1",
        "symbol": "BRIP1",
        "hgnc": "HGNC:20473",
        "name": "BRCA1 interacting DNA helicase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brip1"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "foxe1",
        "symbol": "FOXE1",
        "hgnc": "HGNC:3806",
        "name": "forkhead box E1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxe1"
      },
      {
        "slug": "mre11",
        "symbol": "MRE11",
        "hgnc": "HGNC:7230",
        "name": "MRE11 double strand break repair nuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mre11"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "nthl1",
        "symbol": "NTHL1",
        "hgnc": "HGNC:8028",
        "name": "nth like DNA glycosylase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nthl1"
      },
      {
        "slug": "palb2",
        "symbol": "PALB2",
        "hgnc": "HGNC:26144",
        "name": "partner and localizer of BRCA2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/palb2"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "rad50",
        "symbol": "RAD50",
        "hgnc": "HGNC:9816",
        "name": "RAD50 double strand break repair protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad50"
      },
      {
        "slug": "rad51",
        "symbol": "RAD51",
        "hgnc": "HGNC:9817",
        "name": "RAD51 recombinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51"
      },
      {
        "slug": "rad51c",
        "symbol": "RAD51C",
        "hgnc": "HGNC:9820",
        "name": "RAD51 paralog C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51c"
      },
      {
        "slug": "rad51d",
        "symbol": "RAD51D",
        "hgnc": "HGNC:9823",
        "name": "RAD51 paralog D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad51d"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "hgnc": "HGNC:25662",
        "name": "alpha and gamma adaptin binding protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aagab"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "col14a1",
        "symbol": "COL14A1",
        "hgnc": "HGNC:2191",
        "name": "collagen type XIV alpha 1 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col14a1"
      },
      {
        "slug": "grem1",
        "symbol": "GREM1",
        "hgnc": "HGNC:2001",
        "name": "gremlin 1, DAN family BMP antagonist",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem1"
      },
      {
        "slug": "mdm2",
        "symbol": "MDM2",
        "hgnc": "HGNC:6973",
        "name": "MDM2 proto-oncogene",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdm2"
      },
      {
        "slug": "nab2",
        "symbol": "NAB2",
        "hgnc": "HGNC:7627",
        "name": "NGFI-A binding protein 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nab2"
      },
      {
        "slug": "rnf43",
        "symbol": "RNF43",
        "hgnc": "HGNC:18505",
        "name": "ring finger protein 43",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf43"
      },
      {
        "slug": "stat6",
        "symbol": "STAT6",
        "hgnc": "HGNC:11368",
        "name": "signal transducer and activator of transcription 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat6"
      },
      {
        "slug": "ar",
        "symbol": "AR",
        "hgnc": "HGNC:644",
        "name": "androgen receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ar"
      },
      {
        "slug": "ephb2",
        "symbol": "EPHB2",
        "hgnc": "HGNC:3393",
        "name": "EPH receptor B2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ephb2"
      },
      {
        "slug": "klf6",
        "symbol": "KLF6",
        "hgnc": "HGNC:2235",
        "name": "KLF transcription factor 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf6"
      },
      {
        "slug": "mad1l1",
        "symbol": "MAD1L1",
        "hgnc": "HGNC:6762",
        "name": "mitotic arrest deficient 1 like 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mad1l1"
      },
      {
        "slug": "mxi1",
        "symbol": "MXI1",
        "hgnc": "HGNC:7534",
        "name": "MAX interactor 1, dimerization protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mxi1"
      },
      {
        "slug": "zfhx3",
        "symbol": "ZFHX3",
        "hgnc": "HGNC:777",
        "name": "zinc finger homeobox 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfhx3"
      }
    ]
  }
}