{
  "url": "https://dantelabs.com/traits/prominent-nose",
  "trait": {
    "bundleId": "2026.10.21-777c9289",
    "release": "2026-09-01",
    "slug": "prominent-nose",
    "id": "HP:0000448",
    "name": "Prominent nose",
    "definition": "Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip.",
    "synonyms": [
      "Big nose",
      "Disproportionately large nose",
      "Increased nasal size",
      "Increased size of nose",
      "Large nose",
      "Pronounced nose"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nasal-morphology",
        "name": "Abnormal of nasal shape",
        "url": "https://dantelabs.com/traits/abnormal-nasal-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "acer3",
        "symbol": "ACER3",
        "hgnc": "HGNC:16066",
        "name": "alkaline ceramidase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acer3"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "ash1l",
        "symbol": "ASH1L",
        "hgnc": "HGNC:19088",
        "name": "ASH1 like histone lysine methyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ash1l"
      },
      {
        "slug": "asph",
        "symbol": "ASPH",
        "hgnc": "HGNC:757",
        "name": "aspartate beta-hydroxylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asph"
      },
      {
        "slug": "cdk19",
        "symbol": "CDK19",
        "hgnc": "HGNC:19338",
        "name": "cyclin dependent kinase 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk19"
      },
      {
        "slug": "cdk5rap2",
        "symbol": "CDK5RAP2",
        "hgnc": "HGNC:18672",
        "name": "CDK5 regulatory subunit associated protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk5rap2"
      },
      {
        "slug": "dennd5a",
        "symbol": "DENND5A",
        "hgnc": "HGNC:19344",
        "name": "DENN domain containing 5A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dennd5a"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      },
      {
        "slug": "fbxl3",
        "symbol": "FBXL3",
        "hgnc": "HGNC:13599",
        "name": "F-box and leucine rich repeat protein 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl3"
      },
      {
        "slug": "fem1b",
        "symbol": "FEM1B",
        "hgnc": "HGNC:3649",
        "name": "fem-1 homolog B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fem1b"
      },
      {
        "slug": "gmppa",
        "symbol": "GMPPA",
        "hgnc": "HGNC:22923",
        "name": "GDP-mannose pyrophosphorylase A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gmppa"
      },
      {
        "slug": "hivep2",
        "symbol": "HIVEP2",
        "hgnc": "HGNC:4921",
        "name": "HIVEP zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hivep2"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "intu",
        "symbol": "INTU",
        "hgnc": "HGNC:29239",
        "name": "inturned planar cell polarity protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/intu"
      },
      {
        "slug": "itpr1",
        "symbol": "ITPR1",
        "hgnc": "HGNC:6180",
        "name": "inositol 1,4,5-trisphosphate receptor type 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr1"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "nav3",
        "symbol": "NAV3",
        "hgnc": "HGNC:15998",
        "name": "neuron navigator 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nav3"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "nhs",
        "symbol": "NHS",
        "hgnc": "HGNC:7820",
        "name": "NHS actin remodeling regulator",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhs"
      },
      {
        "slug": "nin",
        "symbol": "NIN",
        "hgnc": "HGNC:14906",
        "name": "ninein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nin"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "pex19",
        "symbol": "PEX19",
        "hgnc": "HGNC:9713",
        "name": "peroxisomal biogenesis factor 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex19"
      },
      {
        "slug": "qrich1",
        "symbol": "QRICH1",
        "hgnc": "HGNC:24713",
        "name": "glutamine rich 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/qrich1"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "rnu4atac",
        "symbol": "RNU4ATAC",
        "hgnc": "HGNC:34016",
        "name": "RNA, U4atac small nuclear",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/rnu4atac"
      },
      {
        "slug": "srcap",
        "symbol": "SRCAP",
        "hgnc": "HGNC:16974",
        "name": "Snf2 related CREBBP activator protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srcap"
      },
      {
        "slug": "stil",
        "symbol": "STIL",
        "hgnc": "HGNC:10879",
        "name": "STIL centriolar assembly protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stil"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "taf6",
        "symbol": "TAF6",
        "hgnc": "HGNC:11540",
        "name": "TATA-box binding protein associated factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf6"
      },
      {
        "slug": "uggt1",
        "symbol": "UGGT1",
        "hgnc": "HGNC:15663",
        "name": "UDP-glucose glycoprotein glucosyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uggt1"
      },
      {
        "slug": "znf668",
        "symbol": "ZNF668",
        "hgnc": "HGNC:25821",
        "name": "zinc finger protein 668",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf668"
      },
      {
        "slug": "cul4b",
        "symbol": "CUL4B",
        "hgnc": "HGNC:2555",
        "name": "cullin 4B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul4b"
      },
      {
        "slug": "emg1",
        "symbol": "EMG1",
        "hgnc": "HGNC:16912",
        "name": "EMG1 N1-specific pseudouridine methyltransferase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/emg1"
      },
      {
        "slug": "gins3",
        "symbol": "GINS3",
        "hgnc": "HGNC:25851",
        "name": "GINS complex subunit 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gins3"
      },
      {
        "slug": "hymai",
        "symbol": "HYMAI",
        "hgnc": "HGNC:5326",
        "name": "hydatidiform mole associated and imprinted",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hymai"
      },
      {
        "slug": "kat6b",
        "symbol": "KAT6B",
        "hgnc": "HGNC:17582",
        "name": "lysine acetyltransferase 6B",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/kat6b"
      },
      {
        "slug": "pcnt",
        "symbol": "PCNT",
        "hgnc": "HGNC:16068",
        "name": "pericentrin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pcnt"
      },
      {
        "slug": "plagl1",
        "symbol": "PLAGL1",
        "hgnc": "HGNC:9046",
        "name": "PLAG1 like zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plagl1"
      },
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "hgnc": "HGNC:20",
        "name": "alanyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars1"
      },
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "hgnc": "HGNC:144",
        "name": "actin gamma 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actg1"
      },
      {
        "slug": "bcl11b",
        "symbol": "BCL11B",
        "hgnc": "HGNC:13222",
        "name": "BCL11 transcription factor B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl11b"
      },
      {
        "slug": "bptf",
        "symbol": "BPTF",
        "hgnc": "HGNC:3581",
        "name": "bromodomain PHD finger transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bptf"
      },
      {
        "slug": "cenpe",
        "symbol": "CENPE",
        "hgnc": "HGNC:1856",
        "name": "centromere protein E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cenpe"
      },
      {
        "slug": "cenpt",
        "symbol": "CENPT",
        "hgnc": "HGNC:25787",
        "name": "centromere protein T",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cenpt"
      },
      {
        "slug": "cog5",
        "symbol": "COG5",
        "hgnc": "HGNC:14857",
        "name": "component of oligomeric golgi complex 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog5"
      },
      {
        "slug": "ctsk",
        "symbol": "CTSK",
        "hgnc": "HGNC:2536",
        "name": "cathepsin K",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctsk"
      },
      {
        "slug": "ep300",
        "symbol": "EP300",
        "hgnc": "HGNC:3373",
        "name": "EP300 lysine acetyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ep300"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "exosc5",
        "symbol": "EXOSC5",
        "hgnc": "HGNC:24662",
        "name": "exosome component 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exosc5"
      },
      {
        "slug": "fgf3",
        "symbol": "FGF3",
        "hgnc": "HGNC:3681",
        "name": "fibroblast growth factor 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgf3"
      },
      {
        "slug": "lmbr1",
        "symbol": "LMBR1",
        "hgnc": "HGNC:13243",
        "name": "limb development membrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbr1"
      },
      {
        "slug": "man1b1",
        "symbol": "MAN1B1",
        "hgnc": "HGNC:6823",
        "name": "mannosidase alpha class 1B member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man1b1"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "psmd12",
        "symbol": "PSMD12",
        "hgnc": "HGNC:9557",
        "name": "proteasome 26S subunit, non-ATPase 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmd12"
      },
      {
        "slug": "ptpmt1",
        "symbol": "PTPMT1",
        "hgnc": "HGNC:26965",
        "name": "protein tyrosine phosphatase mitochondrial 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpmt1"
      },
      {
        "slug": "pum1",
        "symbol": "PUM1",
        "hgnc": "HGNC:14957",
        "name": "pumilio RNA binding family member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pum1"
      },
      {
        "slug": "rusc2",
        "symbol": "RUSC2",
        "hgnc": "HGNC:23625",
        "name": "RUN and SH3 domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rusc2"
      },
      {
        "slug": "slc6a1",
        "symbol": "SLC6A1",
        "hgnc": "HGNC:11042",
        "name": "solute carrier family 6 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a1"
      },
      {
        "slug": "slc6a11",
        "symbol": "SLC6A11",
        "hgnc": "HGNC:11044",
        "name": "solute carrier family 6 member 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a11"
      },
      {
        "slug": "wars1",
        "symbol": "WARS1",
        "hgnc": "HGNC:12729",
        "name": "tryptophanyl-tRNA synthetase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars1"
      },
      {
        "slug": "adat3",
        "symbol": "ADAT3",
        "hgnc": "HGNC:25151",
        "name": "adenosine deaminase tRNA specific 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adat3"
      },
      {
        "slug": "cltcl1",
        "symbol": "CLTCL1",
        "hgnc": "HGNC:2093",
        "name": "clathrin heavy chain like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cltcl1"
      },
      {
        "slug": "cog3",
        "symbol": "COG3",
        "hgnc": "HGNC:18619",
        "name": "component of oligomeric golgi complex 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog3"
      },
      {
        "slug": "crebbp",
        "symbol": "CREBBP",
        "hgnc": "HGNC:2348",
        "name": "CREB binding lysine acetyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crebbp"
      },
      {
        "slug": "dcaf17",
        "symbol": "DCAF17",
        "hgnc": "HGNC:25784",
        "name": "DDB1 and CUL4 associated factor 17",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcaf17"
      },
      {
        "slug": "ebf3",
        "symbol": "EBF3",
        "hgnc": "HGNC:19087",
        "name": "EBF transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebf3"
      },
      {
        "slug": "extl3",
        "symbol": "EXTL3",
        "hgnc": "HGNC:3518",
        "name": "exostosin like glycosyltransferase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/extl3"
      },
      {
        "slug": "fbxo11",
        "symbol": "FBXO11",
        "hgnc": "HGNC:13590",
        "name": "F-box protein 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo11"
      },
      {
        "slug": "filip1",
        "symbol": "FILIP1",
        "hgnc": "HGNC:21015",
        "name": "filamin A interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/filip1"
      },
      {
        "slug": "foxp2",
        "symbol": "FOXP2",
        "hgnc": "HGNC:13875",
        "name": "forkhead box P2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp2"
      },
      {
        "slug": "gnb2",
        "symbol": "GNB2",
        "hgnc": "HGNC:4398",
        "name": "G protein subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb2"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "hnrnpc",
        "symbol": "HNRNPC",
        "hgnc": "HGNC:5035",
        "name": "heterogeneous nuclear ribonucleoprotein C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpc"
      },
      {
        "slug": "mark2",
        "symbol": "MARK2",
        "hgnc": "HGNC:3332",
        "name": "microtubule affinity regulating kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mark2"
      },
      {
        "slug": "minpp1",
        "symbol": "MINPP1",
        "hgnc": "HGNC:7102",
        "name": "multiple inositol-polyphosphate phosphatase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/minpp1"
      },
      {
        "slug": "ophn1",
        "symbol": "OPHN1",
        "hgnc": "HGNC:8148",
        "name": "oligophrenin 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ophn1"
      },
      {
        "slug": "pde4d",
        "symbol": "PDE4D",
        "hgnc": "HGNC:8783",
        "name": "phosphodiesterase 4D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde4d"
      },
      {
        "slug": "pgm2l1",
        "symbol": "PGM2L1",
        "hgnc": "HGNC:20898",
        "name": "phosphoglucomutase 2 like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm2l1"
      },
      {
        "slug": "plaat3",
        "symbol": "PLAAT3",
        "hgnc": "HGNC:17825",
        "name": "phospholipase A and acyltransferase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plaat3"
      },
      {
        "slug": "plk4",
        "symbol": "PLK4",
        "hgnc": "HGNC:11397",
        "name": "polo like kinase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plk4"
      },
      {
        "slug": "slf2",
        "symbol": "SLF2",
        "hgnc": "HGNC:17814",
        "name": "SMC5/6 complex localization factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slf2"
      },
      {
        "slug": "smc5",
        "symbol": "SMC5",
        "hgnc": "HGNC:20465",
        "name": "structural maintenance of chromosomes 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc5"
      },
      {
        "slug": "smg8",
        "symbol": "SMG8",
        "hgnc": "HGNC:25551",
        "name": "SMG8 nonsense mediated mRNA decay factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smg8"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "sox6",
        "symbol": "SOX6",
        "hgnc": "HGNC:16421",
        "name": "SRY-box transcription factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox6"
      },
      {
        "slug": "spart",
        "symbol": "SPART",
        "hgnc": "HGNC:18514",
        "name": "spartin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spart"
      },
      {
        "slug": "spop",
        "symbol": "SPOP",
        "hgnc": "HGNC:11254",
        "name": "speckle type BTB/POZ protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spop"
      },
      {
        "slug": "tbc1d32",
        "symbol": "TBC1D32",
        "hgnc": "HGNC:21485",
        "name": "TBC1 domain family member 32",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d32"
      },
      {
        "slug": "tmem94",
        "symbol": "TMEM94",
        "hgnc": "HGNC:28983",
        "name": "transmembrane protein 94",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem94"
      },
      {
        "slug": "ttc5",
        "symbol": "TTC5",
        "hgnc": "HGNC:19274",
        "name": "tetratricopeptide repeat domain 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc5"
      },
      {
        "slug": "tti2",
        "symbol": "TTI2",
        "hgnc": "HGNC:26262",
        "name": "TELO2 interacting protein 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tti2"
      },
      {
        "slug": "ufc1",
        "symbol": "UFC1",
        "hgnc": "HGNC:26941",
        "name": "ubiquitin-fold modifier conjugating enzyme 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufc1"
      },
      {
        "slug": "usp9x",
        "symbol": "USP9X",
        "hgnc": "HGNC:12632",
        "name": "ubiquitin specific peptidase 9 X-linked",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/usp9x"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "ptbp1",
        "symbol": "PTBP1",
        "hgnc": "HGNC:9583",
        "name": "polypyrimidine tract binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptbp1"
      },
      {
        "slug": "ap1s2",
        "symbol": "AP1S2",
        "hgnc": "HGNC:560",
        "name": "adaptor related protein complex 1 subunit sigma 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s2"
      },
      {
        "slug": "ap4s1",
        "symbol": "AP4S1",
        "hgnc": "HGNC:575",
        "name": "adaptor related protein complex 4 subunit sigma 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap4s1"
      },
      {
        "slug": "atr",
        "symbol": "ATR",
        "hgnc": "HGNC:882",
        "name": "ATR checkpoint kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atr"
      },
      {
        "slug": "blm",
        "symbol": "BLM",
        "hgnc": "HGNC:1058",
        "name": "BLM RecQ like helicase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blm"
      },
      {
        "slug": "cep120",
        "symbol": "CEP120",
        "hgnc": "HGNC:26690",
        "name": "centrosomal protein 120",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep120"
      },
      {
        "slug": "chd3",
        "symbol": "CHD3",
        "hgnc": "HGNC:1918",
        "name": "chromodomain helicase DNA binding protein 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd3"
      },
      {
        "slug": "dync1i2",
        "symbol": "DYNC1I2",
        "hgnc": "HGNC:2964",
        "name": "dynein cytoplasmic 1 intermediate chain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync1i2"
      },
      {
        "slug": "eif4a3",
        "symbol": "EIF4A3",
        "hgnc": "HGNC:18683",
        "name": "eukaryotic translation initiation factor 4A3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4a3"
      },
      {
        "slug": "fhl1",
        "symbol": "FHL1",
        "hgnc": "HGNC:3702",
        "name": "four and a half LIM domains 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fhl1"
      },
      {
        "slug": "gpc4",
        "symbol": "GPC4",
        "hgnc": "HGNC:4452",
        "name": "glypican 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc4"
      },
      {
        "slug": "itga3",
        "symbol": "ITGA3",
        "hgnc": "HGNC:6139",
        "name": "integrin subunit alpha 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga3"
      },
      {
        "slug": "mbd5",
        "symbol": "MBD5",
        "hgnc": "HGNC:20444",
        "name": "methyl-CpG binding domain protein 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbd5"
      },
      {
        "slug": "nsun2",
        "symbol": "NSUN2",
        "hgnc": "HGNC:25994",
        "name": "NOP2/Sun RNA methyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsun2"
      },
      {
        "slug": "pex3",
        "symbol": "PEX3",
        "hgnc": "HGNC:8858",
        "name": "peroxisomal biogenesis factor 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex3"
      },
      {
        "slug": "poc1a",
        "symbol": "POC1A",
        "hgnc": "HGNC:24488",
        "name": "POC1 centriolar protein A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/poc1a"
      },
      {
        "slug": "psmb8",
        "symbol": "PSMB8",
        "hgnc": "HGNC:9545",
        "name": "proteasome 20S subunit beta 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb8"
      },
      {
        "slug": "rbbp8",
        "symbol": "RBBP8",
        "hgnc": "HGNC:9891",
        "name": "RB binding protein 8, endonuclease",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbbp8"
      },
      {
        "slug": "rlim",
        "symbol": "RLIM",
        "hgnc": "HGNC:13429",
        "name": "ring finger protein, LIM domain interacting",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlim"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "unc80",
        "symbol": "UNC80",
        "hgnc": "HGNC:26582",
        "name": "unc-80 subunit of NALCN channel complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc80"
      },
      {
        "slug": "wdr73",
        "symbol": "WDR73",
        "hgnc": "HGNC:25928",
        "name": "WD repeat domain 73",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr73"
      },
      {
        "slug": "wnk3",
        "symbol": "WNK3",
        "hgnc": "HGNC:14543",
        "name": "WNK lysine deficient protein kinase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnk3"
      }
    ]
  }
}