{
  "url": "https://dantelabs.com/traits/podocyte-foot-process-effacement",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "podocyte-foot-process-effacement",
    "id": "HP:0031266",
    "name": "Podocyte foot process effacement",
    "definition": "An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier.",
    "synonyms": [
      "Loss of primary podocyte processes"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-glomerular-visceral-epithelial-cell-morphology",
        "name": "Abnormal glomerular visceral epithelial cell morphology",
        "url": "https://dantelabs.com/traits/abnormal-glomerular-visceral-epithelial-cell-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "daam2",
        "symbol": "DAAM2",
        "hgnc": "HGNC:18143",
        "name": "dishevelled associated activator of morphogenesis 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/daam2"
      },
      {
        "slug": "nos1ap",
        "symbol": "NOS1AP",
        "hgnc": "HGNC:16859",
        "name": "nitric oxide synthase 1 adaptor protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nos1ap"
      },
      {
        "slug": "zap70",
        "symbol": "ZAP70",
        "hgnc": "HGNC:12858",
        "name": "zeta chain of T cell receptor associated protein kinase 70",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zap70"
      },
      {
        "slug": "kirrel1",
        "symbol": "KIRREL1",
        "hgnc": "HGNC:15734",
        "name": "kirre like nephrin family adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kirrel1"
      },
      {
        "slug": "yrdc",
        "symbol": "YRDC",
        "hgnc": "HGNC:28905",
        "name": "yrdC N6-threonylcarbamoyltransferase domain containing",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yrdc"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "avil",
        "symbol": "AVIL",
        "hgnc": "HGNC:14188",
        "name": "advillin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avil"
      },
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "hgnc": "HGNC:2852",
        "name": "diacylglycerol kinase epsilon",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgke"
      },
      {
        "slug": "emp2",
        "symbol": "EMP2",
        "hgnc": "HGNC:3334",
        "name": "epithelial membrane protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emp2"
      },
      {
        "slug": "sgpl1",
        "symbol": "SGPL1",
        "hgnc": "HGNC:10817",
        "name": "sphingosine-1-phosphate lyase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgpl1"
      }
    ]
  }
}