{
  "url": "https://dantelabs.com/traits/pendular-nystagmus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "pendular-nystagmus",
    "id": "HP:0012043",
    "name": "Pendular nystagmus",
    "definition": "Rhythmic, involuntary sinusoidal oscillations of one or both eyes. The waveform of pendular nystagmus may occur in any direction.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "url": "https://dantelabs.com/traits/nystagmus"
      }
    ],
    "narrower": [
      {
        "slug": "horizontal-pendular-nystagmus",
        "name": "Horizontal pendular nystagmus",
        "genes": 9,
        "url": "https://dantelabs.com/traits/horizontal-pendular-nystagmus"
      },
      {
        "slug": "seesaw-nystagmus",
        "name": "Seesaw nystagmus",
        "genes": 5,
        "url": "https://dantelabs.com/traits/seesaw-nystagmus"
      },
      {
        "slug": "spasmus-nutans",
        "name": "Spasmus nutans",
        "genes": 1,
        "url": "https://dantelabs.com/traits/spasmus-nutans"
      }
    ],
    "genes": [
      {
        "slug": "dagla",
        "symbol": "DAGLA",
        "hgnc": "HGNC:1165",
        "name": "diacylglycerol lipase alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dagla"
      },
      {
        "slug": "gfap",
        "symbol": "GFAP",
        "hgnc": "HGNC:4235",
        "name": "glial fibrillary acidic protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfap"
      },
      {
        "slug": "hmgb3",
        "symbol": "HMGB3",
        "hgnc": "HGNC:5004",
        "name": "high mobility group box 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmgb3"
      },
      {
        "slug": "ppox",
        "symbol": "PPOX",
        "hgnc": "HGNC:9280",
        "name": "protoporphyrinogen oxidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppox"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "tmem63a",
        "symbol": "TMEM63A",
        "hgnc": "HGNC:29118",
        "name": "transmembrane protein 63A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem63a"
      },
      {
        "slug": "atf6",
        "symbol": "ATF6",
        "hgnc": "HGNC:791",
        "name": "activating transcription factor 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atf6"
      },
      {
        "slug": "bloc1s3",
        "symbol": "BLOC1S3",
        "hgnc": "HGNC:20914",
        "name": "biogenesis of lysosomal organelles complex 1 subunit 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bloc1s3"
      },
      {
        "slug": "cnga3",
        "symbol": "CNGA3",
        "hgnc": "HGNC:2150",
        "name": "cyclic nucleotide gated channel subunit alpha 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cnga3"
      },
      {
        "slug": "cngb3",
        "symbol": "CNGB3",
        "hgnc": "HGNC:2153",
        "name": "cyclic nucleotide gated channel subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cngb3"
      },
      {
        "slug": "gnat2",
        "symbol": "GNAT2",
        "hgnc": "HGNC:4394",
        "name": "G protein subunit alpha transducin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnat2"
      },
      {
        "slug": "pde6c",
        "symbol": "PDE6C",
        "hgnc": "HGNC:8787",
        "name": "phosphodiesterase 6C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6c"
      },
      {
        "slug": "pde6h",
        "symbol": "PDE6H",
        "hgnc": "HGNC:8790",
        "name": "phosphodiesterase 6H",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6h"
      },
      {
        "slug": "rpgr",
        "symbol": "RPGR",
        "hgnc": "HGNC:10295",
        "name": "retinitis pigmentosa GTPase regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgr"
      },
      {
        "slug": "cnnm4",
        "symbol": "CNNM4",
        "hgnc": "HGNC:105",
        "name": "cyclin and CBS domain divalent metal cation transport mediator 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnnm4"
      },
      {
        "slug": "dlat",
        "symbol": "DLAT",
        "hgnc": "HGNC:2896",
        "name": "dihydrolipoamide S-acetyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlat"
      },
      {
        "slug": "nt5c2",
        "symbol": "NT5C2",
        "hgnc": "HGNC:8022",
        "name": "5'-nucleotidase, cytosolic II",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nt5c2"
      },
      {
        "slug": "plp1",
        "symbol": "PLP1",
        "hgnc": "HGNC:9086",
        "name": "proteolipid protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plp1"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "dnmbp",
        "symbol": "DNMBP",
        "hgnc": "HGNC:30373",
        "name": "dynamin binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmbp"
      },
      {
        "slug": "opn1sw",
        "symbol": "OPN1SW",
        "hgnc": "HGNC:1012",
        "name": "opsin 1, short wave sensitive",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1sw"
      },
      {
        "slug": "pex2",
        "symbol": "PEX2",
        "hgnc": "HGNC:9717",
        "name": "peroxisomal biogenesis factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex2"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "rars1",
        "symbol": "RARS1",
        "hgnc": "HGNC:9870",
        "name": "arginyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rars1"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "aipl1",
        "symbol": "AIPL1",
        "hgnc": "HGNC:359",
        "name": "AIP like 1 HSP90 co-chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aipl1"
      },
      {
        "slug": "atoh7",
        "symbol": "ATOH7",
        "hgnc": "HGNC:13907",
        "name": "atonal bHLH transcription factor 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atoh7"
      },
      {
        "slug": "crx",
        "symbol": "CRX",
        "hgnc": "HGNC:2383",
        "name": "cone-rod homeobox",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crx"
      },
      {
        "slug": "frmd7",
        "symbol": "FRMD7",
        "hgnc": "HGNC:8079",
        "name": "FERM domain containing 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frmd7"
      },
      {
        "slug": "nup62",
        "symbol": "NUP62",
        "hgnc": "HGNC:8066",
        "name": "nucleoporin 62",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup62"
      },
      {
        "slug": "opn1lw",
        "symbol": "OPN1LW",
        "hgnc": "HGNC:9936",
        "name": "opsin 1, long wave sensitive",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1lw"
      },
      {
        "slug": "opn1mw",
        "symbol": "OPN1MW",
        "hgnc": "HGNC:4206",
        "name": "opsin 1, medium wave sensitive",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opn1mw"
      },
      {
        "slug": "rpgrip1",
        "symbol": "RPGRIP1",
        "hgnc": "HGNC:13436",
        "name": "RPGR interacting protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1"
      },
      {
        "slug": "tenm3",
        "symbol": "TENM3",
        "hgnc": "HGNC:29944",
        "name": "teneurin transmembrane protein 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tenm3"
      }
    ]
  }
}