{
  "url": "https://dantelabs.com/traits/nephrotic-range-proteinuria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "nephrotic-range-proteinuria",
    "id": "HP:0012593",
    "name": "Nephrotic range proteinuria",
    "definition": "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "url": "https://dantelabs.com/traits/proteinuria"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cd81",
        "symbol": "CD81",
        "hgnc": "HGNC:1701",
        "name": "CD81 molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd81"
      },
      {
        "slug": "nos1ap",
        "symbol": "NOS1AP",
        "hgnc": "HGNC:16859",
        "name": "nitric oxide synthase 1 adaptor protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nos1ap"
      },
      {
        "slug": "oas2",
        "symbol": "OAS2",
        "hgnc": "HGNC:8087",
        "name": "2'-5'-oligoadenylate synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oas2"
      },
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "hgnc": "HGNC:2852",
        "name": "diacylglycerol kinase epsilon",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgke"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      },
      {
        "slug": "ddost",
        "symbol": "DDOST",
        "hgnc": "HGNC:2728",
        "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddost"
      }
    ]
  }
}