{
  "url": "https://dantelabs.com/traits/mitochondrial-depletion",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "mitochondrial-depletion",
    "id": "HP:0030059",
    "name": "Mitochondrial depletion",
    "definition": "An abnormal reduction in mitochondrial DNA content of cells.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-mitochondrial-metabolism",
        "name": "Abnormality of mitochondrial metabolism",
        "url": "https://dantelabs.com/traits/abnormality-of-mitochondrial-metabolism"
      }
    ],
    "narrower": [
      {
        "slug": "depletion-of-mitochondrial-dna-in-muscle-tissue",
        "name": "Depletion of mitochondrial DNA in muscle tissue",
        "genes": 12,
        "url": "https://dantelabs.com/traits/depletion-of-mitochondrial-dna-in-muscle-tissue"
      },
      {
        "slug": "depletion-of-mitochondrial-dna-in-liver",
        "name": "Depletion of mitochondrial DNA in liver",
        "genes": 3,
        "url": "https://dantelabs.com/traits/depletion-of-mitochondrial-dna-in-liver"
      }
    ],
    "genes": [
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "fbxl4",
        "symbol": "FBXL4",
        "hgnc": "HGNC:13601",
        "name": "F-box and leucine rich repeat protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl4"
      },
      {
        "slug": "neb",
        "symbol": "NEB",
        "hgnc": "HGNC:7720",
        "name": "nebulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neb"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      }
    ]
  }
}