{
  "url": "https://dantelabs.com/traits/mania",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "mania",
    "id": "HP:0100754",
    "name": "Manic",
    "label": "Mania",
    "definition": "A state of abnormally elevated or irritable mood, arousal, and/or energy levels.",
    "synonyms": [
      "Hypomania",
      "Hypomanic"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-emotional-state",
        "name": "Abnormal emotional state",
        "url": "https://dantelabs.com/traits/abnormal-emotional-state"
      },
      {
        "slug": "abnormally-increased-volition",
        "name": "Abnormally increased volition",
        "url": "https://dantelabs.com/traits/abnormally-increased-volition"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "arhgef15",
        "symbol": "ARHGEF15",
        "hgnc": "HGNC:15590",
        "name": "Rho guanine nucleotide exchange factor 15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef15"
      },
      {
        "slug": "armc5",
        "symbol": "ARMC5",
        "hgnc": "HGNC:25781",
        "name": "armadillo repeat containing 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/armc5"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "kdm1a",
        "symbol": "KDM1A",
        "hgnc": "HGNC:29079",
        "name": "lysine demethylase 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm1a"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prnp"
      }
    ]
  }
}