{
  "url": "https://dantelabs.com/traits/macroorchidism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "macroorchidism",
    "id": "HP:0000053",
    "name": "Large testis",
    "label": "Macroorchidism",
    "definition": "The presence of abnormally large testes.",
    "synonyms": [
      "Large testicles"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-testis-size",
        "name": "Abnormality of the testis size",
        "url": "https://dantelabs.com/traits/abnormality-of-the-testis-size"
      }
    ],
    "narrower": [
      {
        "slug": "macroorchidism-postpubertal",
        "name": "Macroorchidism, postpubertal",
        "genes": 2,
        "url": "https://dantelabs.com/traits/macroorchidism-postpubertal"
      },
      {
        "slug": "congenital-macroorchidism",
        "name": "Congenital macroorchidism",
        "genes": 1,
        "url": "https://dantelabs.com/traits/congenital-macroorchidism"
      }
    ],
    "genes": [
      {
        "slug": "rbmx",
        "symbol": "RBMX",
        "hgnc": "HGNC:9910",
        "name": "RNA binding motif protein X-linked",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rbmx"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "aga",
        "symbol": "AGA",
        "hgnc": "HGNC:318",
        "name": "aspartylglucosaminidase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aga"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "hgnc": "HGNC:18060",
        "name": "aristaless related homeobox",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arx"
      },
      {
        "slug": "chd8",
        "symbol": "CHD8",
        "hgnc": "HGNC:20153",
        "name": "chromodomain helicase DNA binding protein 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd8"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "tbc1d7",
        "symbol": "TBC1D7",
        "hgnc": "HGNC:21066",
        "name": "TBC1 domain family member 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d7"
      },
      {
        "slug": "tshb",
        "symbol": "TSHB",
        "hgnc": "HGNC:12372",
        "name": "thyroid stimulating hormone subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshb"
      },
      {
        "slug": "upf3b",
        "symbol": "UPF3B",
        "hgnc": "HGNC:20439",
        "name": "UPF3B regulator of nonsense mediated mRNA decay",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/upf3b"
      },
      {
        "slug": "zdhhc9",
        "symbol": "ZDHHC9",
        "hgnc": "HGNC:18475",
        "name": "zDHHC palmitoyltransferase 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zdhhc9"
      },
      {
        "slug": "akt1",
        "symbol": "AKT1",
        "hgnc": "HGNC:391",
        "name": "AKT serine/threonine kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt1"
      },
      {
        "slug": "clic2",
        "symbol": "CLIC2",
        "hgnc": "HGNC:2063",
        "name": "CLIC family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clic2"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "il1rapl1",
        "symbol": "IL1RAPL1",
        "hgnc": "HGNC:5996",
        "name": "interleukin 1 receptor accessory protein like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il1rapl1"
      },
      {
        "slug": "lhcgr",
        "symbol": "LHCGR",
        "hgnc": "HGNC:6585",
        "name": "luteinizing hormone/choriogonadotropin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhcgr"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "pde11a",
        "symbol": "PDE11A",
        "hgnc": "HGNC:8773",
        "name": "phosphodiesterase 11A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde11a"
      },
      {
        "slug": "prkar1a",
        "symbol": "PRKAR1A",
        "hgnc": "HGNC:9388",
        "name": "protein kinase cAMP-dependent type I regulatory subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1a"
      }
    ]
  }
}