{
  "url": "https://dantelabs.com/traits/leukonychia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "leukonychia",
    "id": "HP:0001820",
    "name": "White discoloration of nails",
    "label": "Leukonychia",
    "definition": "White discoloration of the nails.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-nail-color",
        "name": "Abnormality of nail color",
        "url": "https://dantelabs.com/traits/abnormality-of-nail-color"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cast",
        "symbol": "CAST",
        "hgnc": "HGNC:1515",
        "name": "calpastatin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cast"
      },
      {
        "slug": "dsc3",
        "symbol": "DSC3",
        "hgnc": "HGNC:3037",
        "name": "desmocollin 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsc3"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "hgnc": "HGNC:29300",
        "name": "KN motif and ankyrin repeat domains 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kank2"
      },
      {
        "slug": "plcd1",
        "symbol": "PLCD1",
        "hgnc": "HGNC:9060",
        "name": "phospholipase C delta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcd1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "kif11",
        "symbol": "KIF11",
        "hgnc": "HGNC:6388",
        "name": "kinesin family member 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif11"
      },
      {
        "slug": "pex6",
        "symbol": "PEX6",
        "hgnc": "HGNC:8859",
        "name": "peroxisomal biogenesis factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex6"
      },
      {
        "slug": "trps1",
        "symbol": "TRPS1",
        "hgnc": "HGNC:12340",
        "name": "transcriptional repressor GATA binding 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trps1"
      },
      {
        "slug": "abca12",
        "symbol": "ABCA12",
        "hgnc": "HGNC:14637",
        "name": "ATP binding cassette subfamily A member 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abca12"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "klk11",
        "symbol": "KLK11",
        "hgnc": "HGNC:6359",
        "name": "kallikrein related peptidase 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klk11"
      },
      {
        "slug": "pex1",
        "symbol": "PEX1",
        "hgnc": "HGNC:8850",
        "name": "peroxisomal biogenesis factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex1"
      }
    ]
  }
}