{
  "url": "https://dantelabs.com/traits/increased-hba2-hemoglobin",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-hba2-hemoglobin",
    "id": "HP:0045048",
    "name": "Increased HbA2 hemoglobin",
    "definition": "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia.",
    "synonyms": [
      "Increased haemoglobin A2",
      "Increased HbA2 haemoglobin",
      "Increased hemoglobin A2"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-hemoglobin",
        "name": "Abnormal hemoglobin",
        "url": "https://dantelabs.com/traits/abnormal-hemoglobin"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hbb"
      }
    ]
  }
}