{
  "url": "https://dantelabs.com/traits/inappropriate-laughter",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "inappropriate-laughter",
    "id": "HP:0000748",
    "name": "Inappropriate laughter",
    "definition": "Laughing that may be excessive and/or inappropriate in context (e.g., laughing at a funeral while others are crying).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "social-disinhibition",
        "name": "Social disinhibition",
        "url": "https://dantelabs.com/traits/social-disinhibition"
      }
    ],
    "narrower": [
      {
        "slug": "paroxysmal-bursts-of-laughter",
        "name": "Paroxysmal bursts of laughter",
        "genes": 12,
        "url": "https://dantelabs.com/traits/paroxysmal-bursts-of-laughter"
      }
    ],
    "genes": [
      {
        "slug": "mbd5",
        "symbol": "MBD5",
        "hgnc": "HGNC:20444",
        "name": "methyl-CpG binding domain protein 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbd5"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "atp10a",
        "symbol": "ATP10A",
        "hgnc": "HGNC:13542",
        "name": "ATPase phospholipid transporting 10A (putative)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp10a"
      },
      {
        "slug": "grin1",
        "symbol": "GRIN1",
        "hgnc": "HGNC:4584",
        "name": "glutamate ionotropic receptor NMDA type subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin1"
      },
      {
        "slug": "nova2",
        "symbol": "NOVA2",
        "hgnc": "HGNC:7887",
        "name": "NOVA alternative splicing regulator 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nova2"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "pde2a",
        "symbol": "PDE2A",
        "hgnc": "HGNC:8777",
        "name": "phosphodiesterase 2A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde2a"
      },
      {
        "slug": "pgap1",
        "symbol": "PGAP1",
        "hgnc": "HGNC:25712",
        "name": "post-GPI attachment to proteins inositol deacylase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap1"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "tbc1d2b",
        "symbol": "TBC1D2B",
        "hgnc": "HGNC:29183",
        "name": "TBC1 domain family member 2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d2b"
      },
      {
        "slug": "ube3a",
        "symbol": "UBE3A",
        "hgnc": "HGNC:12496",
        "name": "ubiquitin protein ligase E3A",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ube3a"
      },
      {
        "slug": "cdkl5",
        "symbol": "CDKL5",
        "hgnc": "HGNC:11411",
        "name": "cyclin dependent kinase like 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkl5"
      },
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "gabbr2",
        "symbol": "GABBR2",
        "hgnc": "HGNC:4507",
        "name": "gamma-aminobutyric acid type B receptor subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabbr2"
      },
      {
        "slug": "gatad2b",
        "symbol": "GATAD2B",
        "hgnc": "HGNC:30778",
        "name": "GATA zinc finger domain containing 2B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gatad2b"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "ntng1",
        "symbol": "NTNG1",
        "hgnc": "HGNC:23319",
        "name": "netrin G1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ntng1"
      },
      {
        "slug": "pigs",
        "symbol": "PIGS",
        "hgnc": "HGNC:14937",
        "name": "phosphatidylinositol glycan anchor biosynthesis class S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigs"
      },
      {
        "slug": "slc6a17",
        "symbol": "SLC6A17",
        "hgnc": "HGNC:31399",
        "name": "solute carrier family 6 member 17",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc6a17"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "ywhaz",
        "symbol": "YWHAZ",
        "hgnc": "HGNC:12855",
        "name": "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ywhaz"
      },
      {
        "slug": "adsl",
        "symbol": "ADSL",
        "hgnc": "HGNC:291",
        "name": "adenylosuccinate lyase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adsl"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/psen1"
      }
    ]
  }
}