{
  "url": "https://dantelabs.com/traits/hypoplastic-ischia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-ischia",
    "id": "HP:0003175",
    "name": "Hypoplastic ischia",
    "definition": "Underdevelopment of the ischium, which forms the lower and back part of the hip bone.",
    "synonyms": [
      "Hypoplastic ischial bones",
      "Hypoplastic ischii",
      "Hypoplastic ischium"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ischium-morphology",
        "name": "Abnormal ischium morphology",
        "url": "https://dantelabs.com/traits/abnormal-ischium-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "hypoplastic-ischiopubic-ramus",
        "name": "Hypoplastic ischiopubic ramus",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypoplastic-ischiopubic-ramus"
      }
    ],
    "genes": [
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "ccdc8",
        "symbol": "CCDC8",
        "hgnc": "HGNC:25367",
        "name": "coiled-coil domain containing 8 subunit of 3M complex",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc8"
      },
      {
        "slug": "cul7",
        "symbol": "CUL7",
        "hgnc": "HGNC:21024",
        "name": "cullin 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul7"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "kat6b",
        "symbol": "KAT6B",
        "hgnc": "HGNC:17582",
        "name": "lysine acetyltransferase 6B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kat6b"
      },
      {
        "slug": "obsl1",
        "symbol": "OBSL1",
        "hgnc": "HGNC:29092",
        "name": "obscurin like cytoskeletal adaptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/obsl1"
      },
      {
        "slug": "ift43",
        "symbol": "IFT43",
        "hgnc": "HGNC:29669",
        "name": "intraflagellar transport 43",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift43"
      },
      {
        "slug": "hspg2",
        "symbol": "HSPG2",
        "hgnc": "HGNC:5273",
        "name": "heparan sulfate proteoglycan 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspg2"
      },
      {
        "slug": "cdca7",
        "symbol": "CDCA7",
        "hgnc": "HGNC:14628",
        "name": "cell division cycle associated 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdca7"
      },
      {
        "slug": "col11a1",
        "symbol": "COL11A1",
        "hgnc": "HGNC:2186",
        "name": "collagen type XI alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a1"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "pam16",
        "symbol": "PAM16",
        "hgnc": "HGNC:29679",
        "name": "presequence translocase associated motor 16",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pam16"
      },
      {
        "slug": "tbx15",
        "symbol": "TBX15",
        "hgnc": "HGNC:11594",
        "name": "T-box transcription factor 15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx15"
      },
      {
        "slug": "trip11",
        "symbol": "TRIP11",
        "hgnc": "HGNC:12305",
        "name": "thyroid hormone receptor interactor 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trip11"
      }
    ]
  }
}