{
  "url": "https://dantelabs.com/traits/hyponatremia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hyponatremia",
    "id": "HP:0002902",
    "name": "Low blood sodium levels",
    "label": "Hyponatremia",
    "definition": "The concentration of sodium in the blood circulation is below the lower limit of normal.",
    "synonyms": [
      "Decreased sodium(1+) concentration",
      "Decreased sodium(1+) level",
      "Decreased sodium(1+) level in blood",
      "Reduced sodium(1+) concentration",
      "Reduced sodium(1+) level",
      "Reduced sodium(1+) level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-sodium-concentration",
        "name": "Abnormal circulating sodium concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-sodium-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "atic",
        "symbol": "ATIC",
        "hgnc": "HGNC:794",
        "name": "5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atic"
      },
      {
        "slug": "avpr2",
        "symbol": "AVPR2",
        "hgnc": "HGNC:897",
        "name": "arginine vasopressin receptor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avpr2"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "cyp11b2",
        "symbol": "CYP11B2",
        "hgnc": "HGNC:2592",
        "name": "cytochrome P450 family 11 subfamily B member 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/cyp11b2"
      },
      {
        "slug": "nup214",
        "symbol": "NUP214",
        "hgnc": "HGNC:8064",
        "name": "nucleoporin 214",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup214"
      },
      {
        "slug": "plvap",
        "symbol": "PLVAP",
        "hgnc": "HGNC:13635",
        "name": "plasmalemma vesicle associated protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plvap"
      },
      {
        "slug": "sars2",
        "symbol": "SARS2",
        "hgnc": "HGNC:17697",
        "name": "seryl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sars2"
      },
      {
        "slug": "scnn1a",
        "symbol": "SCNN1A",
        "hgnc": "HGNC:10599",
        "name": "sodium channel epithelial 1 subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1a"
      },
      {
        "slug": "scnn1g",
        "symbol": "SCNN1G",
        "hgnc": "HGNC:10602",
        "name": "sodium channel epithelial 1 subunit gamma",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1g"
      },
      {
        "slug": "cyp11a1",
        "symbol": "CYP11A1",
        "hgnc": "HGNC:2590",
        "name": "cytochrome P450 family 11 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp11a1"
      },
      {
        "slug": "nfkb2",
        "symbol": "NFKB2",
        "hgnc": "HGNC:7795",
        "name": "nuclear factor kappa B subunit 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkb2"
      },
      {
        "slug": "ocrl",
        "symbol": "OCRL",
        "hgnc": "HGNC:8108",
        "name": "OCRL inositol polyphosphate-5-phosphatase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ocrl"
      },
      {
        "slug": "scnn1b",
        "symbol": "SCNN1B",
        "hgnc": "HGNC:10600",
        "name": "sodium channel epithelial 1 subunit beta",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scnn1b"
      },
      {
        "slug": "tbx19",
        "symbol": "TBX19",
        "hgnc": "HGNC:11596",
        "name": "T-box transcription factor 19",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx19"
      },
      {
        "slug": "alg8",
        "symbol": "ALG8",
        "hgnc": "HGNC:23161",
        "name": "ALG8 alpha-1,3-glucosyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg8"
      },
      {
        "slug": "bsnd",
        "symbol": "BSND",
        "hgnc": "HGNC:16512",
        "name": "barttin CLCNK type accessory subunit beta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bsnd"
      },
      {
        "slug": "clcnka",
        "symbol": "CLCNKA",
        "hgnc": "HGNC:2026",
        "name": "chloride voltage-gated channel Ka",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcnka"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "dzip1l",
        "symbol": "DZIP1L",
        "hgnc": "HGNC:26551",
        "name": "DAZ interacting zinc finger protein 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dzip1l"
      },
      {
        "slug": "gemin4",
        "symbol": "GEMIN4",
        "hgnc": "HGNC:15717",
        "name": "gem nuclear organelle associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gemin4"
      },
      {
        "slug": "hsd3b2",
        "symbol": "HSD3B2",
        "hgnc": "HGNC:5218",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hsd3b2"
      },
      {
        "slug": "mc2r",
        "symbol": "MC2R",
        "hgnc": "HGNC:6930",
        "name": "melanocortin 2 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc2r"
      },
      {
        "slug": "mrap",
        "symbol": "MRAP",
        "hgnc": "HGNC:1304",
        "name": "melanocortin 2 receptor accessory protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrap"
      },
      {
        "slug": "ndufb8",
        "symbol": "NDUFB8",
        "hgnc": "HGNC:7703",
        "name": "NADH:ubiquinone oxidoreductase subunit B8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb8"
      },
      {
        "slug": "nnt",
        "symbol": "NNT",
        "hgnc": "HGNC:7863",
        "name": "nicotinamide nucleotide transhydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nnt"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr3c2",
        "symbol": "NR3C2",
        "hgnc": "HGNC:7979",
        "name": "nuclear receptor subfamily 3 group C member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr3c2"
      },
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "hgnc": "HGNC:19903",
        "name": "Ras related GTP binding D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragd"
      },
      {
        "slug": "setd2",
        "symbol": "SETD2",
        "hgnc": "HGNC:18420",
        "name": "SET domain containing 2, histone lysine methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd2"
      },
      {
        "slug": "star",
        "symbol": "STAR",
        "hgnc": "HGNC:11359",
        "name": "steroidogenic acute regulatory protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/star"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "ticam1",
        "symbol": "TICAM1",
        "hgnc": "HGNC:18348",
        "name": "TIR domain containing adaptor molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ticam1"
      },
      {
        "slug": "tlr3",
        "symbol": "TLR3",
        "hgnc": "HGNC:11849",
        "name": "toll like receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr3"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "tsfm",
        "symbol": "TSFM",
        "hgnc": "HGNC:12367",
        "name": "Ts translation elongation factor, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsfm"
      },
      {
        "slug": "txnrd2",
        "symbol": "TXNRD2",
        "hgnc": "HGNC:18155",
        "name": "thioredoxin reductase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txnrd2"
      },
      {
        "slug": "unc93b1",
        "symbol": "UNC93B1",
        "hgnc": "HGNC:13481",
        "name": "unc-93B1 regulator of TLR signaling",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc93b1"
      },
      {
        "slug": "alad",
        "symbol": "ALAD",
        "hgnc": "HGNC:395",
        "name": "aminolevulinate dehydratase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alad"
      },
      {
        "slug": "ap1s3",
        "symbol": "AP1S3",
        "hgnc": "HGNC:18971",
        "name": "adaptor related protein complex 1 subunit sigma 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s3"
      },
      {
        "slug": "atp6v1b1",
        "symbol": "ATP6V1B1",
        "hgnc": "HGNC:853",
        "name": "ATPase H+ transporting V1 subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b1"
      },
      {
        "slug": "cd4",
        "symbol": "CD4",
        "hgnc": "HGNC:1678",
        "name": "CD4 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd4"
      },
      {
        "slug": "cpox",
        "symbol": "CPOX",
        "hgnc": "HGNC:2321",
        "name": "coproporphyrinogen oxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpox"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "hgnc": "HGNC:5959",
        "name": "elongator acetyltransferase complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp1"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "il36rn",
        "symbol": "IL36RN",
        "hgnc": "HGNC:15561",
        "name": "interleukin 36 receptor antagonist",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il36rn"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "pbx1",
        "symbol": "PBX1",
        "hgnc": "HGNC:8632",
        "name": "PBX homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pbx1"
      },
      {
        "slug": "ppox",
        "symbol": "PPOX",
        "hgnc": "HGNC:9280",
        "name": "protoporphyrinogen oxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppox"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      },
      {
        "slug": "alg12",
        "symbol": "ALG12",
        "hgnc": "HGNC:19358",
        "name": "ALG12 alpha-1,6-mannosyltransferase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg12"
      },
      {
        "slug": "eif2ak3",
        "symbol": "EIF2AK3",
        "hgnc": "HGNC:3255",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak3"
      },
      {
        "slug": "ca12",
        "symbol": "CA12",
        "hgnc": "HGNC:1371",
        "name": "carbonic anhydrase 12",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca12"
      },
      {
        "slug": "maged2",
        "symbol": "MAGED2",
        "hgnc": "HGNC:16353",
        "name": "MAGE family member D2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/maged2"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "samd9",
        "symbol": "SAMD9",
        "hgnc": "HGNC:1348",
        "name": "sterile alpha motif domain containing 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd9"
      },
      {
        "slug": "slc26a3",
        "symbol": "SLC26A3",
        "hgnc": "HGNC:3018",
        "name": "solute carrier family 26 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a3"
      },
      {
        "slug": "tdp2",
        "symbol": "TDP2",
        "hgnc": "HGNC:17768",
        "name": "tyrosyl-DNA phosphodiesterase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tdp2"
      }
    ]
  }
}