{
  "url": "https://dantelabs.com/traits/hypoargininemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypoargininemia",
    "id": "HP:0005961",
    "name": "Low blood arginine levels",
    "label": "Hypoargininemia",
    "definition": "The concentration of arginine in the blood circulation is below the lower limit of normal.",
    "synonyms": [
      "Decreased arginine concentration",
      "Decreased arginine level",
      "Decreased arginine level in blood",
      "Reduced arginine concentration",
      "Reduced arginine level",
      "Reduced arginine level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-arginine-concentration",
        "name": "Abnormal circulating arginine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-arginine-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "asl",
        "symbol": "ASL",
        "hgnc": "HGNC:746",
        "name": "argininosuccinate lyase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/asl"
      },
      {
        "slug": "cps1",
        "symbol": "CPS1",
        "hgnc": "HGNC:2323",
        "name": "carbamoyl-phosphate synthase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cps1"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "otc",
        "symbol": "OTC",
        "hgnc": "HGNC:8512",
        "name": "ornithine transcarbamylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otc"
      },
      {
        "slug": "pnpo",
        "symbol": "PNPO",
        "hgnc": "HGNC:30260",
        "name": "pyridoxamine 5'-phosphate oxidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpo"
      },
      {
        "slug": "ass1",
        "symbol": "ASS1",
        "hgnc": "HGNC:758",
        "name": "argininosuccinate synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ass1"
      }
    ]
  }
}