{
  "url": "https://dantelabs.com/traits/hypergonadotropic-hypogonadism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypergonadotropic-hypogonadism",
    "id": "HP:0000815",
    "name": "Hypergonadotropic hypogonadism",
    "definition": "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.",
    "synonyms": [
      "Hypergonadotrophic hypogonadism",
      "Primary hypogonadism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "hypogonadism",
        "name": "Decreased activity of gonads",
        "url": "https://dantelabs.com/traits/hypogonadism"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bmp15",
        "symbol": "BMP15",
        "hgnc": "HGNC:1068",
        "name": "bone morphogenetic protein 15",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp15"
      },
      {
        "slug": "bmpr1b",
        "symbol": "BMPR1B",
        "hgnc": "HGNC:1077",
        "name": "bone morphogenetic protein receptor type 1B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1b"
      },
      {
        "slug": "dhh",
        "symbol": "DHH",
        "hgnc": "HGNC:2865",
        "name": "desert hedgehog signaling molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhh"
      },
      {
        "slug": "lepr",
        "symbol": "LEPR",
        "hgnc": "HGNC:6554",
        "name": "leptin receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lepr"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "scp2",
        "symbol": "SCP2",
        "hgnc": "HGNC:10606",
        "name": "sterol carrier protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scp2"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "sry",
        "symbol": "SRY",
        "hgnc": "HGNC:11311",
        "name": "sex determining region Y",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sry"
      },
      {
        "slug": "cyb5a",
        "symbol": "CYB5A",
        "hgnc": "HGNC:2570",
        "name": "cytochrome b5 type A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyb5a"
      },
      {
        "slug": "cyp17a1",
        "symbol": "CYP17A1",
        "hgnc": "HGNC:2593",
        "name": "cytochrome P450 family 17 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp17a1"
      },
      {
        "slug": "cyp19a1",
        "symbol": "CYP19A1",
        "hgnc": "HGNC:2594",
        "name": "cytochrome P450 family 19 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp19a1"
      },
      {
        "slug": "dhx37",
        "symbol": "DHX37",
        "hgnc": "HGNC:17210",
        "name": "DEAH-box helicase 37",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx37"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "lep",
        "symbol": "LEP",
        "hgnc": "HGNC:6553",
        "name": "leptin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lep"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "map3k1",
        "symbol": "MAP3K1",
        "hgnc": "HGNC:6848",
        "name": "mitogen-activated protein kinase kinase kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k1"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "polr1c",
        "symbol": "POLR1C",
        "hgnc": "HGNC:20194",
        "name": "RNA polymerase I and III subunit C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1c"
      },
      {
        "slug": "polr3a",
        "symbol": "POLR3A",
        "hgnc": "HGNC:30074",
        "name": "RNA polymerase III subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3a"
      },
      {
        "slug": "polr3b",
        "symbol": "POLR3B",
        "hgnc": "HGNC:30348",
        "name": "RNA polymerase III subunit B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3b"
      },
      {
        "slug": "sil1",
        "symbol": "SIL1",
        "hgnc": "HGNC:24624",
        "name": "SIL1 nucleotide exchange factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sil1"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "vamp7",
        "symbol": "VAMP7",
        "hgnc": "HGNC:11486",
        "name": "vesicle associated membrane protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp7"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "wwox",
        "symbol": "WWOX",
        "hgnc": "HGNC:12799",
        "name": "WW domain containing oxidoreductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wwox"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "ahsg",
        "symbol": "AHSG",
        "hgnc": "HGNC:349",
        "name": "alpha 2-HS glycoprotein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahsg"
      },
      {
        "slug": "alms1",
        "symbol": "ALMS1",
        "hgnc": "HGNC:428",
        "name": "ALMS1 centrosome and basal body associated protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/alms1"
      },
      {
        "slug": "brcc3",
        "symbol": "BRCC3",
        "hgnc": "HGNC:24185",
        "name": "BRCA1/BRCA2-containing complex subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brcc3"
      },
      {
        "slug": "itgb6",
        "symbol": "ITGB6",
        "hgnc": "HGNC:6161",
        "name": "integrin subunit beta 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb6"
      },
      {
        "slug": "lss",
        "symbol": "LSS",
        "hgnc": "HGNC:6708",
        "name": "lanosterol synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lss"
      },
      {
        "slug": "manf",
        "symbol": "MANF",
        "hgnc": "HGNC:15461",
        "name": "mesencephalic astrocyte derived neurotrophic factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/manf"
      },
      {
        "slug": "mrps7",
        "symbol": "MRPS7",
        "hgnc": "HGNC:14499",
        "name": "mitochondrial ribosomal protein S7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps7"
      },
      {
        "slug": "prorp",
        "symbol": "PRORP",
        "hgnc": "HGNC:19958",
        "name": "protein only RNase P catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prorp"
      },
      {
        "slug": "foxl2",
        "symbol": "FOXL2",
        "hgnc": "HGNC:1092",
        "name": "forkhead box L2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxl2"
      },
      {
        "slug": "galk1",
        "symbol": "GALK1",
        "hgnc": "HGNC:4118",
        "name": "galactokinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galk1"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "lig3",
        "symbol": "LIG3",
        "hgnc": "HGNC:6600",
        "name": "DNA ligase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig3"
      },
      {
        "slug": "mre11",
        "symbol": "MRE11",
        "hgnc": "HGNC:7230",
        "name": "MRE11 double strand break repair nuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mre11"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "rin2",
        "symbol": "RIN2",
        "hgnc": "HGNC:18750",
        "name": "Ras and Rab interactor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rin2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "samd9",
        "symbol": "SAMD9",
        "hgnc": "HGNC:1348",
        "name": "sterile alpha motif domain containing 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd9"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tymp"
      },
      {
        "slug": "zbtb20",
        "symbol": "ZBTB20",
        "hgnc": "HGNC:13503",
        "name": "zinc finger and BTB domain containing 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb20"
      },
      {
        "slug": "fancd2",
        "symbol": "FANCD2",
        "hgnc": "HGNC:3585",
        "name": "FA complementation group D2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancd2"
      },
      {
        "slug": "mgme1",
        "symbol": "MGME1",
        "hgnc": "HGNC:16205",
        "name": "mitochondrial genome maintenance exonuclease 1",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mgme1"
      },
      {
        "slug": "amacr",
        "symbol": "AMACR",
        "hgnc": "HGNC:451",
        "name": "alpha-methylacyl-CoA racemase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amacr"
      },
      {
        "slug": "aptx",
        "symbol": "APTX",
        "hgnc": "HGNC:15984",
        "name": "aprataxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aptx"
      },
      {
        "slug": "clpp",
        "symbol": "CLPP",
        "hgnc": "HGNC:2084",
        "name": "caseinolytic mitochondrial matrix peptidase proteolytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpp"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "ctdp1",
        "symbol": "CTDP1",
        "hgnc": "HGNC:2498",
        "name": "CTD phosphatase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctdp1"
      },
      {
        "slug": "dcaf17",
        "symbol": "DCAF17",
        "hgnc": "HGNC:25784",
        "name": "DDB1 and CUL4 associated factor 17",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcaf17"
      },
      {
        "slug": "fanca",
        "symbol": "FANCA",
        "hgnc": "HGNC:3582",
        "name": "FA complementation group A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanca"
      },
      {
        "slug": "fancb",
        "symbol": "FANCB",
        "hgnc": "HGNC:3583",
        "name": "FA complementation group B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancb"
      },
      {
        "slug": "fancc",
        "symbol": "FANCC",
        "hgnc": "HGNC:3584",
        "name": "FA complementation group C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancc"
      },
      {
        "slug": "fance",
        "symbol": "FANCE",
        "hgnc": "HGNC:3586",
        "name": "FA complementation group E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fance"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "lhcgr",
        "symbol": "LHCGR",
        "hgnc": "HGNC:6585",
        "name": "luteinizing hormone/choriogonadotropin receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhcgr"
      },
      {
        "slug": "pmm2",
        "symbol": "PMM2",
        "hgnc": "HGNC:9115",
        "name": "phosphomannomutase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmm2"
      },
      {
        "slug": "slc29a3",
        "symbol": "SLC29A3",
        "hgnc": "HGNC:23096",
        "name": "solute carrier family 29 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc29a3"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twnk"
      }
    ]
  }
}