{
  "url": "https://dantelabs.com/traits/hsv-encephalitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hsv-encephalitis",
    "id": "HP:0012302",
    "name": "HSV encephalitis",
    "definition": "Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction.",
    "synonyms": [
      "Herpes encephalitis",
      "Herpes simplex encephalitis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "unusual-hsv-infection",
        "name": "Unusual HSV infection",
        "url": "https://dantelabs.com/traits/unusual-hsv-infection"
      },
      {
        "slug": "viral-encephalitis",
        "name": "Viral encephalitis",
        "url": "https://dantelabs.com/traits/viral-encephalitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hyou1",
        "symbol": "HYOU1",
        "hgnc": "HGNC:16931",
        "name": "hypoxia up-regulated 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyou1"
      },
      {
        "slug": "snora31",
        "symbol": "SNORA31",
        "hgnc": "HGNC:32621",
        "name": "small nucleolar RNA, H/ACA box 31",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snora31"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "ticam1",
        "symbol": "TICAM1",
        "hgnc": "HGNC:18348",
        "name": "TIR domain containing adaptor molecule 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ticam1"
      },
      {
        "slug": "tlr3",
        "symbol": "TLR3",
        "hgnc": "HGNC:11849",
        "name": "toll like receptor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr3"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "irf3",
        "symbol": "IRF3",
        "hgnc": "HGNC:6118",
        "name": "interferon regulatory factor 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf3"
      },
      {
        "slug": "nckap1l",
        "symbol": "NCKAP1L",
        "hgnc": "HGNC:4862",
        "name": "NCK associated protein 1 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nckap1l"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "unc93b1",
        "symbol": "UNC93B1",
        "hgnc": "HGNC:13481",
        "name": "unc-93B1 regulator of TLR signaling",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc93b1"
      }
    ]
  }
}