{
  "url": "https://dantelabs.com/traits/hepatic-necrosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hepatic-necrosis",
    "id": "HP:0002605",
    "name": "Hepatic necrosis",
    "definition": "The presence of cell death (necrosis) affecting the liver.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-liver-morphology",
        "name": "Abnormal liver morphology",
        "url": "https://dantelabs.com/traits/abnormal-liver-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "hepatocellular-necrosis",
        "name": "Death of liver cells",
        "genes": 3,
        "url": "https://dantelabs.com/traits/hepatocellular-necrosis"
      },
      {
        "slug": "hepatic-periportal-necrosis",
        "name": "Hepatic periportal necrosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/hepatic-periportal-necrosis"
      }
    ],
    "genes": [
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "met",
        "symbol": "MET",
        "hgnc": "HGNC:7029",
        "name": "MET proto-oncogene, receptor tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/met"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "hadh",
        "symbol": "HADH",
        "hgnc": "HGNC:4799",
        "name": "hydroxyacyl-CoA dehydrogenase",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hadh"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      }
    ]
  }
}