{
  "url": "https://dantelabs.com/traits/glycosuria",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "glycosuria",
    "id": "HP:0003076",
    "name": "Glucose in urine",
    "label": "Glycosuria",
    "definition": "An increased concentration of glucose in the urine.",
    "synonyms": [
      "Glucosuria"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-urinary-organic-compound-level",
        "name": "Abnormal urinary organic compound level",
        "url": "https://dantelabs.com/traits/abnormal-urinary-organic-compound-level"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "gatm",
        "symbol": "GATM",
        "hgnc": "HGNC:4175",
        "name": "glycine amidinotransferase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gatm"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc2a2"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "slc5a2",
        "symbol": "SLC5A2",
        "hgnc": "HGNC:11037",
        "name": "solute carrier family 5 member 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc5a2"
      },
      {
        "slug": "vipas39",
        "symbol": "VIPAS39",
        "hgnc": "HGNC:20347",
        "name": "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vipas39"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "ehhadh",
        "symbol": "EHHADH",
        "hgnc": "HGNC:3247",
        "name": "enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ehhadh"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "hgnc": "HGNC:6081",
        "name": "insulin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ins"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "hgnc": "HGNC:6257",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj11"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "pdx1",
        "symbol": "PDX1",
        "hgnc": "HGNC:6107",
        "name": "pancreatic and duodenal homeobox 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdx1"
      },
      {
        "slug": "stat3",
        "symbol": "STAT3",
        "hgnc": "HGNC:11364",
        "name": "signal transducer and activator of transcription 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat3"
      },
      {
        "slug": "appl1",
        "symbol": "APPL1",
        "hgnc": "HGNC:24035",
        "name": "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/appl1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "cel",
        "symbol": "CEL",
        "hgnc": "HGNC:1848",
        "name": "carboxyl ester lipase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cel"
      },
      {
        "slug": "coa8",
        "symbol": "COA8",
        "hgnc": "HGNC:20492",
        "name": "cytochrome c oxidase assembly factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa8"
      },
      {
        "slug": "fan1",
        "symbol": "FAN1",
        "hgnc": "HGNC:29170",
        "name": "FANCD2 and FANCI associated nuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fan1"
      },
      {
        "slug": "gys2",
        "symbol": "GYS2",
        "hgnc": "HGNC:4707",
        "name": "glycogen synthase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys2"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "hgnc": "HGNC:11630",
        "name": "HNF1 homeobox B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "klf11",
        "symbol": "KLF11",
        "hgnc": "HGNC:11811",
        "name": "KLF transcription factor 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf11"
      },
      {
        "slug": "neurod1",
        "symbol": "NEUROD1",
        "hgnc": "HGNC:7762",
        "name": "neuronal differentiation 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurod1"
      },
      {
        "slug": "pax4",
        "symbol": "PAX4",
        "hgnc": "HGNC:8618",
        "name": "paired box 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax4"
      },
      {
        "slug": "slc16a12",
        "symbol": "SLC16A12",
        "hgnc": "HGNC:23094",
        "name": "solute carrier family 16 member 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc16a12"
      },
      {
        "slug": "trmt5",
        "symbol": "TRMT5",
        "hgnc": "HGNC:23141",
        "name": "tRNA methyltransferase 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt5"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "pbx1",
        "symbol": "PBX1",
        "hgnc": "HGNC:8632",
        "name": "PBX homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pbx1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "atp7b",
        "symbol": "ATP7B",
        "hgnc": "HGNC:870",
        "name": "ATPase copper transporting beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7b"
      },
      {
        "slug": "clcn5",
        "symbol": "CLCN5",
        "hgnc": "HGNC:2023",
        "name": "Cl-/H+ antiporter 5",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcn5"
      },
      {
        "slug": "cox10",
        "symbol": "COX10",
        "hgnc": "HGNC:2260",
        "name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox10"
      },
      {
        "slug": "cox15",
        "symbol": "COX15",
        "hgnc": "HGNC:2263",
        "name": "cytochrome c oxidase assembly factor COX15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox15"
      },
      {
        "slug": "cox6b1",
        "symbol": "COX6B1",
        "hgnc": "HGNC:2280",
        "name": "cytochrome c oxidase subunit 6B1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox6b1"
      },
      {
        "slug": "etfa",
        "symbol": "ETFA",
        "hgnc": "HGNC:3481",
        "name": "electron transfer flavoprotein subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfa"
      },
      {
        "slug": "etfb",
        "symbol": "ETFB",
        "hgnc": "HGNC:3482",
        "name": "electron transfer flavoprotein subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfb"
      },
      {
        "slug": "etfdh",
        "symbol": "ETFDH",
        "hgnc": "HGNC:3483",
        "name": "electron transfer flavoprotein dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfdh"
      },
      {
        "slug": "fastkd2",
        "symbol": "FASTKD2",
        "hgnc": "HGNC:29160",
        "name": "FASTK mitochondrial RNA regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd2"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "hgnc": "HGNC:4174",
        "name": "GATA binding protein 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata6"
      },
      {
        "slug": "mt-tn",
        "symbol": "MT-TN",
        "hgnc": "HGNC:7493",
        "name": "mitochondrially encoded tRNA-Asn (AAU/C)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tn"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "nsmce2",
        "symbol": "NSMCE2",
        "hgnc": "HGNC:26513",
        "name": "NSE2 SUMO ligase component of SMC5/6 complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsmce2"
      },
      {
        "slug": "sco1",
        "symbol": "SCO1",
        "hgnc": "HGNC:10603",
        "name": "synthesis of cytochrome C oxidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco1"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "slc5a1",
        "symbol": "SLC5A1",
        "hgnc": "HGNC:11036",
        "name": "solute carrier family 5 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a1"
      },
      {
        "slug": "surf1",
        "symbol": "SURF1",
        "hgnc": "HGNC:11474",
        "name": "SURF1 cytochrome c oxidase assembly factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/surf1"
      },
      {
        "slug": "taco1",
        "symbol": "TACO1",
        "hgnc": "HGNC:24316",
        "name": "translational activator of cytochrome c oxidase I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taco1"
      }
    ]
  }
}