{
  "url": "https://dantelabs.com/traits/glioma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "glioma",
    "id": "HP:0009733",
    "name": "Glioma",
    "definition": "The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-glial-cell-morphology",
        "name": "Abnormal glial cell morphology",
        "url": "https://dantelabs.com/traits/abnormal-glial-cell-morphology"
      },
      {
        "slug": "malignant-neoplasm-of-the-central-nervous-system",
        "name": "Malignant neoplasm of the central nervous system",
        "url": "https://dantelabs.com/traits/malignant-neoplasm-of-the-central-nervous-system"
      },
      {
        "slug": "neuroepithelial-neoplasm",
        "name": "Neuroepithelial neoplasm",
        "url": "https://dantelabs.com/traits/neuroepithelial-neoplasm"
      }
    ],
    "narrower": [
      {
        "slug": "astrocytoma",
        "name": "Astrocytoma",
        "genes": 25,
        "url": "https://dantelabs.com/traits/astrocytoma"
      },
      {
        "slug": "glioblastoma-multiforme",
        "name": "Glioblastoma multiforme",
        "genes": 24,
        "url": "https://dantelabs.com/traits/glioblastoma-multiforme"
      },
      {
        "slug": "ependymoma",
        "name": "Ependymoma",
        "genes": 17,
        "url": "https://dantelabs.com/traits/ependymoma"
      },
      {
        "slug": "optic-nerve-glioma",
        "name": "Optic nerve glioma",
        "genes": 6,
        "url": "https://dantelabs.com/traits/optic-nerve-glioma"
      },
      {
        "slug": "oligodendroglioma",
        "name": "Oligodendroglioma",
        "genes": 2,
        "url": "https://dantelabs.com/traits/oligodendroglioma"
      },
      {
        "slug": "brainstem-glioma",
        "name": "Brainstem glioma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/brainstem-glioma"
      },
      {
        "slug": "cerebellar-glioma",
        "name": "Cerebellar glioma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cerebellar-glioma"
      }
    ],
    "genes": [
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "nbn",
        "symbol": "NBN",
        "hgnc": "HGNC:7652",
        "name": "nibrin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nbn"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      }
    ]
  }
}