{
  "url": "https://dantelabs.com/traits/generalized-osteosclerosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "generalized-osteosclerosis",
    "id": "HP:0005789",
    "name": "Increased bone density in skeletal bones",
    "label": "Generalized osteosclerosis",
    "definition": "An abnormal increase of bone mineral density with generalized involvement of the skeleton.",
    "synonyms": [
      "Diffuse, symmetrical osteosclerosis",
      "Generalised osteosclerosis",
      "Osteosclerosis, diffuse symmetrical"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/lrp5"
      },
      {
        "slug": "sost",
        "symbol": "SOST",
        "hgnc": "HGNC:13771",
        "name": "sclerostin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sost"
      },
      {
        "slug": "ctsk",
        "symbol": "CTSK",
        "hgnc": "HGNC:2536",
        "name": "cathepsin K",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsk"
      },
      {
        "slug": "dhcr24",
        "symbol": "DHCR24",
        "hgnc": "HGNC:2859",
        "name": "24-dehydrocholesterol reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr24"
      },
      {
        "slug": "plekhm1",
        "symbol": "PLEKHM1",
        "hgnc": "HGNC:29017",
        "name": "pleckstrin homology and RUN domain containing M1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhm1"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "phex",
        "symbol": "PHEX",
        "hgnc": "HGNC:8918",
        "name": "phosphate regulating endopeptidase X-linked",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phex"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      }
    ]
  }
}