{
  "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "focal-segmental-glomerulosclerosis",
    "id": "HP:0000097",
    "name": "Focal segmental glomerulosclerosis",
    "definition": "Segmental accumulation of scar tissue in individual (but not all) glomeruli.",
    "synonyms": [
      "Focal and segmental glomerular sclerosis",
      "Focal and segmental glomerulosclerosis",
      "focal glomerulosclerosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "glomerular-sclerosis",
        "name": "Glomerular sclerosis",
        "url": "https://dantelabs.com/traits/glomerular-sclerosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "actn4",
        "symbol": "ACTN4",
        "hgnc": "HGNC:166",
        "name": "actinin alpha 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/actn4"
      },
      {
        "slug": "anln",
        "symbol": "ANLN",
        "hgnc": "HGNC:14082",
        "name": "anillin, actin binding protein",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/anln"
      },
      {
        "slug": "aptx",
        "symbol": "APTX",
        "hgnc": "HGNC:15984",
        "name": "aprataxin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aptx"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "crb2",
        "symbol": "CRB2",
        "hgnc": "HGNC:18688",
        "name": "crumbs cell polarity complex component 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/crb2"
      },
      {
        "slug": "daam2",
        "symbol": "DAAM2",
        "hgnc": "HGNC:18143",
        "name": "dishevelled associated activator of morphogenesis 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/daam2"
      },
      {
        "slug": "ggcx",
        "symbol": "GGCX",
        "hgnc": "HGNC:4247",
        "name": "gamma-glutamyl carboxylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ggcx"
      },
      {
        "slug": "itga3",
        "symbol": "ITGA3",
        "hgnc": "HGNC:6139",
        "name": "integrin subunit alpha 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga3"
      },
      {
        "slug": "lama5",
        "symbol": "LAMA5",
        "hgnc": "HGNC:6485",
        "name": "laminin subunit alpha 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lama5"
      },
      {
        "slug": "myo1e",
        "symbol": "MYO1E",
        "hgnc": "HGNC:7599",
        "name": "myosin IE",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myo1e"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "nup133",
        "symbol": "NUP133",
        "hgnc": "HGNC:18016",
        "name": "nucleoporin 133",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nup133"
      },
      {
        "slug": "nup85",
        "symbol": "NUP85",
        "hgnc": "HGNC:8734",
        "name": "nucleoporin 85",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nup85"
      },
      {
        "slug": "nup93",
        "symbol": "NUP93",
        "hgnc": "HGNC:28958",
        "name": "nucleoporin 93",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nup93"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smarcal1"
      },
      {
        "slug": "tprkb",
        "symbol": "TPRKB",
        "hgnc": "HGNC:24259",
        "name": "TP53RK binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tprkb"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "coq6",
        "symbol": "COQ6",
        "hgnc": "HGNC:20233",
        "name": "coenzyme Q6, monooxygenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq6"
      },
      {
        "slug": "coq8b",
        "symbol": "COQ8B",
        "hgnc": "HGNC:19041",
        "name": "coenzyme Q8B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq8b"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "ankfy1",
        "symbol": "ANKFY1",
        "hgnc": "HGNC:20763",
        "name": "ankyrin repeat and FYVE domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankfy1"
      },
      {
        "slug": "apol1",
        "symbol": "APOL1",
        "hgnc": "HGNC:618",
        "name": "apolipoprotein L1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/apol1"
      },
      {
        "slug": "arhgap24",
        "symbol": "ARHGAP24",
        "hgnc": "HGNC:25361",
        "name": "Rho GTPase activating protein 24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgap24"
      },
      {
        "slug": "arhgdia",
        "symbol": "ARHGDIA",
        "hgnc": "HGNC:678",
        "name": "Rho GDP dissociation inhibitor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgdia"
      },
      {
        "slug": "avil",
        "symbol": "AVIL",
        "hgnc": "HGNC:14188",
        "name": "advillin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avil"
      },
      {
        "slug": "cd2ap",
        "symbol": "CD2AP",
        "hgnc": "HGNC:14258",
        "name": "CD2 associated protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cd2ap"
      },
      {
        "slug": "col4a3",
        "symbol": "COL4A3",
        "hgnc": "HGNC:2204",
        "name": "collagen type IV alpha 3 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col4a3"
      },
      {
        "slug": "emp2",
        "symbol": "EMP2",
        "hgnc": "HGNC:3334",
        "name": "epithelial membrane protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emp2"
      },
      {
        "slug": "gapvd1",
        "symbol": "GAPVD1",
        "hgnc": "HGNC:23375",
        "name": "GTPase activating protein and VPS9 domains 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gapvd1"
      },
      {
        "slug": "inf2",
        "symbol": "INF2",
        "hgnc": "HGNC:23791",
        "name": "inverted formin 2",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/inf2"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "hgnc": "HGNC:29300",
        "name": "KN motif and ankyrin repeat domains 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kank2"
      },
      {
        "slug": "kirrel1",
        "symbol": "KIRREL1",
        "hgnc": "HGNC:15734",
        "name": "kirre like nephrin family adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kirrel1"
      },
      {
        "slug": "lage3",
        "symbol": "LAGE3",
        "hgnc": "HGNC:26058",
        "name": "L antigen family member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lage3"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "lmx1b",
        "symbol": "LMX1B",
        "hgnc": "HGNC:6654",
        "name": "LIM homeobox transcription factor 1 beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmx1b"
      },
      {
        "slug": "magi2",
        "symbol": "MAGI2",
        "hgnc": "HGNC:18957",
        "name": "membrane associated guanylate kinase, WW and PDZ domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magi2"
      },
      {
        "slug": "mtx2",
        "symbol": "MTX2",
        "hgnc": "HGNC:7506",
        "name": "metaxin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtx2"
      },
      {
        "slug": "nop10",
        "symbol": "NOP10",
        "hgnc": "HGNC:14378",
        "name": "NOP10 ribonucleoprotein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nop10"
      },
      {
        "slug": "nphs1",
        "symbol": "NPHS1",
        "hgnc": "HGNC:7908",
        "name": "NPHS1 adhesion molecule, nephrin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphs1"
      },
      {
        "slug": "nphs2",
        "symbol": "NPHS2",
        "hgnc": "HGNC:13394",
        "name": "NPHS2 stomatin family member, podocin",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nphs2"
      },
      {
        "slug": "nup160",
        "symbol": "NUP160",
        "hgnc": "HGNC:18017",
        "name": "nucleoporin 160",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nup160"
      },
      {
        "slug": "nup205",
        "symbol": "NUP205",
        "hgnc": "HGNC:18658",
        "name": "nucleoporin 205",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nup205"
      },
      {
        "slug": "nup37",
        "symbol": "NUP37",
        "hgnc": "HGNC:29929",
        "name": "nucleoporin 37",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup37"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "plce1",
        "symbol": "PLCE1",
        "hgnc": "HGNC:17175",
        "name": "phospholipase C epsilon 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plce1"
      },
      {
        "slug": "ptpro",
        "symbol": "PTPRO",
        "hgnc": "HGNC:9678",
        "name": "protein tyrosine phosphatase receptor type O",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ptpro"
      },
      {
        "slug": "sgpl1",
        "symbol": "SGPL1",
        "hgnc": "HGNC:10817",
        "name": "sphingosine-1-phosphate lyase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgpl1"
      },
      {
        "slug": "tbc1d8b",
        "symbol": "TBC1D8B",
        "hgnc": "HGNC:24715",
        "name": "TBC1 domain family member 8B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbc1d8b"
      },
      {
        "slug": "trpc6",
        "symbol": "TRPC6",
        "hgnc": "HGNC:12338",
        "name": "transient receptor potential cation channel subfamily C member 6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trpc6"
      },
      {
        "slug": "vps33a",
        "symbol": "VPS33A",
        "hgnc": "HGNC:18179",
        "name": "VPS33A core subunit of CORVET and HOPS complexes",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33a"
      },
      {
        "slug": "wdr4",
        "symbol": "WDR4",
        "hgnc": "HGNC:12756",
        "name": "WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr4"
      },
      {
        "slug": "col4a4",
        "symbol": "COL4A4",
        "hgnc": "HGNC:2206",
        "name": "collagen type IV alpha 4 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a4"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co2",
        "symbol": "MT-CO2",
        "hgnc": "HGNC:7421",
        "name": "mitochondrially encoded cytochrome c oxidase II",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co2"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tf",
        "symbol": "MT-TF",
        "hgnc": "HGNC:7481",
        "name": "mitochondrially encoded tRNA-Phe (UUU/C)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tf"
      },
      {
        "slug": "mt-th",
        "symbol": "MT-TH",
        "hgnc": "HGNC:7487",
        "name": "mitochondrially encoded tRNA-His (CAU/C)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-th"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "mt-tq",
        "symbol": "MT-TQ",
        "hgnc": "HGNC:7495",
        "name": "mitochondrially encoded tRNA-Gln (CAA/G)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tq"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "tp53rk",
        "symbol": "TP53RK",
        "hgnc": "HGNC:16197",
        "name": "TP53 regulating kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53rk"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "jag1",
        "symbol": "JAG1",
        "hgnc": "HGNC:6188",
        "name": "jagged canonical Notch ligand 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jag1"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "clcn5",
        "symbol": "CLCN5",
        "hgnc": "HGNC:2023",
        "name": "Cl-/H+ antiporter 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcn5"
      },
      {
        "slug": "g6pc1",
        "symbol": "G6PC1",
        "hgnc": "HGNC:4056",
        "name": "glucose-6-phosphatase catalytic subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pc1"
      },
      {
        "slug": "nars2",
        "symbol": "NARS2",
        "hgnc": "HGNC:26274",
        "name": "asparaginyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars2"
      },
      {
        "slug": "ren",
        "symbol": "REN",
        "hgnc": "HGNC:9958",
        "name": "renin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ren"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "wdr73",
        "symbol": "WDR73",
        "hgnc": "HGNC:25928",
        "name": "WD repeat domain 73",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr73"
      }
    ]
  }
}