{
  "url": "https://dantelabs.com/traits/fiber-type-grouping",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "fiber-type-grouping",
    "id": "HP:0033685",
    "name": "Fiber type grouping",
    "definition": "An abnormal distribution of muscle fiber types in muscle tissue. Human skeletal muscle contains at least two fiber types recognizable by histochemical techniques. In transverse sections of normal skeletal muscle, type 1 and type 2 fibers are distributed in a random fashion. Grouping of fibers of the same type can be seen in certain peripheral neuropathies, thought to be due to reinnervation of denervated muscle fibers by sprouting axons. With grouping, motor units enlarge. The fibers of a motor unit, which are normally scattered, come to lie adjacent to one another. Histochemical examination shows groups of muscle fibers of the same histochemical type.",
    "synonyms": [
      "Fibre type grouping"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-muscle-fiber-type-distribution",
        "name": "Abnormal muscle fiber-type distribution",
        "url": "https://dantelabs.com/traits/abnormal-muscle-fiber-type-distribution"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "col6a1",
        "symbol": "COL6A1",
        "hgnc": "HGNC:2211",
        "name": "collagen type VI alpha 1 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a1"
      },
      {
        "slug": "dars2",
        "symbol": "DARS2",
        "hgnc": "HGNC:25538",
        "name": "aspartyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dars2"
      },
      {
        "slug": "emilin1",
        "symbol": "EMILIN1",
        "hgnc": "HGNC:19880",
        "name": "elastin microfibril interfacer 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emilin1"
      },
      {
        "slug": "hspb8",
        "symbol": "HSPB8",
        "hgnc": "HGNC:30171",
        "name": "heat shock protein family B (small) member 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspb8"
      },
      {
        "slug": "myh14",
        "symbol": "MYH14",
        "hgnc": "HGNC:23212",
        "name": "myosin heavy chain 14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh14"
      },
      {
        "slug": "reep1",
        "symbol": "REEP1",
        "hgnc": "HGNC:25786",
        "name": "receptor accessory protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reep1"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "wsb2",
        "symbol": "WSB2",
        "hgnc": "HGNC:19222",
        "name": "WD repeat and SOCS box containing 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wsb2"
      },
      {
        "slug": "yme1l1",
        "symbol": "YME1L1",
        "hgnc": "HGNC:12843",
        "name": "YME1 like 1 ATPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yme1l1"
      },
      {
        "slug": "bag3",
        "symbol": "BAG3",
        "hgnc": "HGNC:939",
        "name": "BAG cochaperone 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bag3"
      },
      {
        "slug": "gdap1",
        "symbol": "GDAP1",
        "hgnc": "HGNC:15968",
        "name": "ganglioside induced differentiation associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdap1"
      },
      {
        "slug": "lrp12",
        "symbol": "LRP12",
        "hgnc": "HGNC:31708",
        "name": "LDL receptor related protein 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp12"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "slc5a6",
        "symbol": "SLC5A6",
        "hgnc": "HGNC:11041",
        "name": "solute carrier family 5 member 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a6"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "tpm2",
        "symbol": "TPM2",
        "hgnc": "HGNC:12011",
        "name": "tropomyosin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpm2"
      },
      {
        "slug": "anxa11",
        "symbol": "ANXA11",
        "hgnc": "HGNC:535",
        "name": "annexin A11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anxa11"
      }
    ]
  }
}