{
  "url": "https://dantelabs.com/traits/fasting-hyperinsulinemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "fasting-hyperinsulinemia",
    "id": "HP:0008283",
    "name": "High blood insulin levels while fasting",
    "label": "Fasting hyperinsulinemia",
    "definition": "An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "hyperinsulinemia",
        "name": "Hyperinsulinemia",
        "url": "https://dantelabs.com/traits/hyperinsulinemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "hadh",
        "symbol": "HADH",
        "hgnc": "HGNC:4799",
        "name": "hydroxyacyl-CoA dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadh"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "cdkn1b",
        "symbol": "CDKN1B",
        "hgnc": "HGNC:1785",
        "name": "cyclin dependent kinase inhibitor 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1b"
      },
      {
        "slug": "glud1",
        "symbol": "GLUD1",
        "hgnc": "HGNC:4335",
        "name": "glutamate dehydrogenase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glud1"
      },
      {
        "slug": "pappa2",
        "symbol": "PAPPA2",
        "hgnc": "HGNC:14615",
        "name": "pappalysin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pappa2"
      }
    ]
  }
}