{
  "url": "https://dantelabs.com/traits/facial-hypotonia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "facial-hypotonia",
    "id": "HP:0000297",
    "name": "Decreased facial muscle tone",
    "label": "Facial hypotonia",
    "definition": "Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve).",
    "synonyms": [
      "Low facial muscle tone",
      "Reduced facial muscle tone",
      "Hypotonic facies"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-facial-musculature",
        "name": "Abnormality of facial muscles",
        "url": "https://dantelabs.com/traits/abnormality-of-facial-musculature"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "url": "https://dantelabs.com/traits/hypotonia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dync1h1",
        "symbol": "DYNC1H1",
        "hgnc": "HGNC:2961",
        "name": "dynein cytoplasmic 1 heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync1h1"
      },
      {
        "slug": "elfn1",
        "symbol": "ELFN1",
        "hgnc": "HGNC:33154",
        "name": "extracellular leucine rich repeat and fibronectin type III domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elfn1"
      },
      {
        "slug": "gpc3",
        "symbol": "GPC3",
        "hgnc": "HGNC:4451",
        "name": "glypican 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpc3"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "satb2",
        "symbol": "SATB2",
        "hgnc": "HGNC:21637",
        "name": "SATB homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/satb2"
      },
      {
        "slug": "slc30a9",
        "symbol": "SLC30A9",
        "hgnc": "HGNC:1329",
        "name": "solute carrier family 30 member 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a9"
      },
      {
        "slug": "unc80",
        "symbol": "UNC80",
        "hgnc": "HGNC:26582",
        "name": "unc-80 subunit of NALCN channel complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc80"
      },
      {
        "slug": "champ1",
        "symbol": "CHAMP1",
        "hgnc": "HGNC:20311",
        "name": "chromosome alignment maintaining phosphoprotein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/champ1"
      },
      {
        "slug": "dmpk",
        "symbol": "DMPK",
        "hgnc": "HGNC:2933",
        "name": "DM1 protein kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmpk"
      },
      {
        "slug": "ap4b1",
        "symbol": "AP4B1",
        "hgnc": "HGNC:572",
        "name": "adaptor related protein complex 4 subunit beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap4b1"
      },
      {
        "slug": "ap4e1",
        "symbol": "AP4E1",
        "hgnc": "HGNC:573",
        "name": "adaptor related protein complex 4 subunit epsilon 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap4e1"
      },
      {
        "slug": "ap4m1",
        "symbol": "AP4M1",
        "hgnc": "HGNC:574",
        "name": "adaptor related protein complex 4 subunit mu 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap4m1"
      },
      {
        "slug": "ap4s1",
        "symbol": "AP4S1",
        "hgnc": "HGNC:575",
        "name": "adaptor related protein complex 4 subunit sigma 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap4s1"
      },
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "gaa",
        "symbol": "GAA",
        "hgnc": "HGNC:4065",
        "name": "alpha glucosidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gaa"
      },
      {
        "slug": "kcnk4",
        "symbol": "KCNK4",
        "hgnc": "HGNC:6279",
        "name": "potassium two pore domain channel subfamily K member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk4"
      },
      {
        "slug": "kdm4b",
        "symbol": "KDM4B",
        "hgnc": "HGNC:29136",
        "name": "lysine demethylase 4B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm4b"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "ppp2r1a",
        "symbol": "PPP2R1A",
        "hgnc": "HGNC:9302",
        "name": "protein phosphatase 2 scaffold subunit Aalpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ppp2r1a"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "tet3",
        "symbol": "TET3",
        "hgnc": "HGNC:28313",
        "name": "tet methylcytosine dioxygenase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet3"
      },
      {
        "slug": "xylt2",
        "symbol": "XYLT2",
        "hgnc": "HGNC:15517",
        "name": "xylosyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt2"
      },
      {
        "slug": "atp1a2",
        "symbol": "ATP1A2",
        "hgnc": "HGNC:800",
        "name": "ATPase Na+/K+ transporting subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a2"
      },
      {
        "slug": "atp1a3",
        "symbol": "ATP1A3",
        "hgnc": "HGNC:801",
        "name": "ATPase Na+/K+ transporting subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a3"
      },
      {
        "slug": "borcs8",
        "symbol": "BORCS8",
        "hgnc": "HGNC:37247",
        "name": "BLOC-1 related complex subunit 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs8"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "hgnc": "HGNC:4573",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria3"
      },
      {
        "slug": "herc1",
        "symbol": "HERC1",
        "hgnc": "HGNC:4867",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc1"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "mt-tl2",
        "symbol": "MT-TL2",
        "hgnc": "HGNC:7491",
        "name": "mitochondrially encoded tRNA-Leu (CUN) 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl2"
      },
      {
        "slug": "myot",
        "symbol": "MYOT",
        "hgnc": "HGNC:12399",
        "name": "myotilin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myot"
      },
      {
        "slug": "pax7",
        "symbol": "PAX7",
        "hgnc": "HGNC:8621",
        "name": "paired box 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax7"
      },
      {
        "slug": "pou3f3",
        "symbol": "POU3F3",
        "hgnc": "HGNC:9216",
        "name": "POU class 3 homeobox 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou3f3"
      },
      {
        "slug": "pura",
        "symbol": "PURA",
        "hgnc": "HGNC:9701",
        "name": "purine rich element binding protein A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pura"
      },
      {
        "slug": "rab11b",
        "symbol": "RAB11B",
        "hgnc": "HGNC:9761",
        "name": "RAB11B, member RAS oncogene family",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab11b"
      },
      {
        "slug": "rhobtb2",
        "symbol": "RHOBTB2",
        "hgnc": "HGNC:18756",
        "name": "Rho related BTB domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhobtb2"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "set",
        "symbol": "SET",
        "hgnc": "HGNC:10760",
        "name": "SET nuclear proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/set"
      },
      {
        "slug": "slc1a3",
        "symbol": "SLC1A3",
        "hgnc": "HGNC:10941",
        "name": "solute carrier family 1 member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc1a3"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "srrm2",
        "symbol": "SRRM2",
        "hgnc": "HGNC:16639",
        "name": "serine/arginine repetitive matrix 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srrm2"
      },
      {
        "slug": "strada",
        "symbol": "STRADA",
        "hgnc": "HGNC:30172",
        "name": "STE20 related adaptor alpha",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/strada"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "zscan10",
        "symbol": "ZSCAN10",
        "hgnc": "HGNC:12997",
        "name": "zinc finger and SCAN domain containing 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zscan10"
      },
      {
        "slug": "aldh3a2",
        "symbol": "ALDH3A2",
        "hgnc": "HGNC:403",
        "name": "aldehyde dehydrogenase 3 family member A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh3a2"
      },
      {
        "slug": "ampd2",
        "symbol": "AMPD2",
        "hgnc": "HGNC:469",
        "name": "adenosine monophosphate deaminase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ampd2"
      },
      {
        "slug": "camk2g",
        "symbol": "CAMK2G",
        "hgnc": "HGNC:1463",
        "name": "calcium/calmodulin dependent protein kinase II gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2g"
      },
      {
        "slug": "dse",
        "symbol": "DSE",
        "hgnc": "HGNC:21144",
        "name": "dermatan sulfate epimerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dse"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "pcgf2",
        "symbol": "PCGF2",
        "hgnc": "HGNC:12929",
        "name": "polycomb group ring finger 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcgf2"
      },
      {
        "slug": "ppp2r5d",
        "symbol": "PPP2R5D",
        "hgnc": "HGNC:9312",
        "name": "protein phosphatase 2 regulatory subunit B'delta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r5d"
      },
      {
        "slug": "vps13b",
        "symbol": "VPS13B",
        "hgnc": "HGNC:2183",
        "name": "vacuolar protein sorting 13 homolog B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13b"
      },
      {
        "slug": "zbtb11",
        "symbol": "ZBTB11",
        "hgnc": "HGNC:16740",
        "name": "zinc finger and BTB domain containing 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb11"
      },
      {
        "slug": "zmiz1",
        "symbol": "ZMIZ1",
        "hgnc": "HGNC:16493",
        "name": "zinc finger MIZ-type containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmiz1"
      }
    ]
  }
}