{
  "url": "https://dantelabs.com/traits/facial-edema",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "facial-edema",
    "id": "HP:0000282",
    "name": "Facial puffiness",
    "label": "Facial edema",
    "synonyms": [
      "Facial swelling",
      "Facial oedema",
      "Swelling of the face"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-facial-soft-tissue",
        "name": "Abnormality of facial soft tissue",
        "url": "https://dantelabs.com/traits/abnormality-of-facial-soft-tissue"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "url": "https://dantelabs.com/traits/edema"
      }
    ],
    "narrower": [
      {
        "slug": "periorbital-edema",
        "name": "Periorbital edema",
        "genes": 70,
        "url": "https://dantelabs.com/traits/periorbital-edema"
      }
    ],
    "genes": [
      {
        "slug": "myof",
        "symbol": "MYOF",
        "hgnc": "HGNC:3656",
        "name": "myoferlin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myof"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "kng1",
        "symbol": "KNG1",
        "hgnc": "HGNC:6383",
        "name": "kininogen 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kng1"
      },
      {
        "slug": "serping1",
        "symbol": "SERPING1",
        "hgnc": "HGNC:1228",
        "name": "serpin family G member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serping1"
      },
      {
        "slug": "xpnpep2",
        "symbol": "XPNPEP2",
        "hgnc": "HGNC:12823",
        "name": "X-prolyl aminopeptidase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpnpep2"
      },
      {
        "slug": "foxe1",
        "symbol": "FOXE1",
        "hgnc": "HGNC:3806",
        "name": "forkhead box E1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxe1"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "lhx3",
        "symbol": "LHX3",
        "hgnc": "HGNC:6595",
        "name": "LIM homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx3"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "nkx2-1",
        "symbol": "NKX2-1",
        "hgnc": "HGNC:11825",
        "name": "NK2 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-1"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "pou1f1",
        "symbol": "POU1F1",
        "hgnc": "HGNC:9210",
        "name": "POU class 1 homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou1f1"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "tshb",
        "symbol": "TSHB",
        "hgnc": "HGNC:12372",
        "name": "thyroid stimulating hormone subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshb"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "alb",
        "symbol": "ALB",
        "hgnc": "HGNC:399",
        "name": "albumin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alb"
      },
      {
        "slug": "anapc1",
        "symbol": "ANAPC1",
        "hgnc": "HGNC:19988",
        "name": "anaphase promoting complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anapc1"
      },
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "hgnc": "HGNC:13273",
        "name": "dual oxidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "duoxa2",
        "symbol": "DUOXA2",
        "hgnc": "HGNC:32698",
        "name": "dual oxidase maturation factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duoxa2"
      },
      {
        "slug": "ephb4",
        "symbol": "EPHB4",
        "hgnc": "HGNC:3395",
        "name": "EPH receptor B4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ephb4"
      },
      {
        "slug": "gjc2",
        "symbol": "GJC2",
        "hgnc": "HGNC:17494",
        "name": "gap junction protein gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjc2"
      },
      {
        "slug": "iyd",
        "symbol": "IYD",
        "hgnc": "HGNC:21071",
        "name": "iodotyrosine deiodinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iyd"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "slc5a5",
        "symbol": "SLC5A5",
        "hgnc": "HGNC:11040",
        "name": "solute carrier family 5 member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a5"
      },
      {
        "slug": "tg",
        "symbol": "TG",
        "hgnc": "HGNC:11764",
        "name": "thyroglobulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tg"
      },
      {
        "slug": "tpo",
        "symbol": "TPO",
        "hgnc": "HGNC:12015",
        "name": "thyroid peroxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpo"
      },
      {
        "slug": "havcr2",
        "symbol": "HAVCR2",
        "hgnc": "HGNC:18437",
        "name": "hepatitis A virus cellular receptor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/havcr2"
      },
      {
        "slug": "angpt1",
        "symbol": "ANGPT1",
        "hgnc": "HGNC:484",
        "name": "angiopoietin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/angpt1"
      },
      {
        "slug": "f12",
        "symbol": "F12",
        "hgnc": "HGNC:3530",
        "name": "coagulation factor XII",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f12"
      },
      {
        "slug": "hs3st6",
        "symbol": "HS3ST6",
        "hgnc": "HGNC:14178",
        "name": "heparan sulfate-glucosamine 3-sulfotransferase 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs3st6"
      },
      {
        "slug": "neu1",
        "symbol": "NEU1",
        "hgnc": "HGNC:7758",
        "name": "neuraminidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neu1"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      },
      {
        "slug": "plg",
        "symbol": "PLG",
        "hgnc": "HGNC:9071",
        "name": "plasminogen",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plg"
      }
    ]
  }
}