{
  "url": "https://dantelabs.com/traits/extremely-elevated-creatine-kinase",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "extremely-elevated-creatine-kinase",
    "id": "HP:0030235",
    "name": "Extremely elevated creatine kinase",
    "definition": "An increased creatine kinase level more than 50X above the upper normal level.",
    "synonyms": [
      "Extremely elevated CPK",
      "Extremely elevated creatine phosphokinase",
      "Extremely elevated phospho-CK serum level",
      "Extremely elevated serum CK level",
      "Extremely high CPK level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "elevated-circulating-creatine-kinase-activity",
        "name": "Elevated blood creatine phosphokinase",
        "url": "https://dantelabs.com/traits/elevated-circulating-creatine-kinase-activity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "micu1",
        "symbol": "MICU1",
        "hgnc": "HGNC:1530",
        "name": "mitochondrial calcium uptake 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micu1"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "hgnc": "HGNC:3756",
        "name": "filamin C",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnc"
      }
    ]
  }
}