{
  "url": "https://dantelabs.com/traits/enterocolitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "enterocolitis",
    "id": "HP:0004387",
    "name": "Enterocolitis",
    "definition": "An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "colitis",
        "name": "Colitis",
        "url": "https://dantelabs.com/traits/colitis"
      }
    ],
    "narrower": [
      {
        "slug": "necrotizing-enterocolitis",
        "name": "Necrotizing enterocolitis",
        "genes": 7,
        "url": "https://dantelabs.com/traits/necrotizing-enterocolitis"
      }
    ],
    "genes": [
      {
        "slug": "copz1",
        "symbol": "COPZ1",
        "hgnc": "HGNC:2243",
        "name": "coat protein complex I subunit zeta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copz1"
      },
      {
        "slug": "il10ra",
        "symbol": "IL10RA",
        "hgnc": "HGNC:5964",
        "name": "interleukin 10 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10ra"
      },
      {
        "slug": "il10rb",
        "symbol": "IL10RB",
        "hgnc": "HGNC:5965",
        "name": "interleukin 10 receptor subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10rb"
      },
      {
        "slug": "nop10",
        "symbol": "NOP10",
        "hgnc": "HGNC:14378",
        "name": "NOP10 ribonucleoprotein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nop10"
      },
      {
        "slug": "pik3cg",
        "symbol": "PIK3CG",
        "hgnc": "HGNC:8978",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cg"
      },
      {
        "slug": "plcg2",
        "symbol": "PLCG2",
        "hgnc": "HGNC:9066",
        "name": "phospholipase C gamma 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg2"
      },
      {
        "slug": "spout1",
        "symbol": "SPOUT1",
        "hgnc": "HGNC:26933",
        "name": "SPOUT domain containing methyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spout1"
      },
      {
        "slug": "ttc7a",
        "symbol": "TTC7A",
        "hgnc": "HGNC:19750",
        "name": "tetratricopeptide repeat domain 7A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc7a"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "ece1",
        "symbol": "ECE1",
        "hgnc": "HGNC:3146",
        "name": "endothelin converting enzyme 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ece1"
      },
      {
        "slug": "edn3",
        "symbol": "EDN3",
        "hgnc": "HGNC:3178",
        "name": "endothelin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edn3"
      },
      {
        "slug": "ednrb",
        "symbol": "EDNRB",
        "hgnc": "HGNC:3180",
        "name": "endothelin receptor type B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednrb"
      },
      {
        "slug": "erbb2",
        "symbol": "ERBB2",
        "hgnc": "HGNC:3430",
        "name": "erb-b2 receptor tyrosine kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb2"
      },
      {
        "slug": "erbb3",
        "symbol": "ERBB3",
        "hgnc": "HGNC:3431",
        "name": "erb-b2 receptor tyrosine kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erbb3"
      },
      {
        "slug": "gdnf",
        "symbol": "GDNF",
        "hgnc": "HGNC:4232",
        "name": "glial cell derived neurotrophic factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdnf"
      },
      {
        "slug": "nrtn",
        "symbol": "NRTN",
        "hgnc": "HGNC:8007",
        "name": "neurturin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nrtn"
      },
      {
        "slug": "oplah",
        "symbol": "OPLAH",
        "hgnc": "HGNC:8149",
        "name": "5-oxoprolinase, ATP-hydrolysing",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/oplah"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "sema3c",
        "symbol": "SEMA3C",
        "hgnc": "HGNC:10725",
        "name": "semaphorin 3C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3c"
      },
      {
        "slug": "sema3d",
        "symbol": "SEMA3D",
        "hgnc": "HGNC:10726",
        "name": "semaphorin 3D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3d"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "srebf1",
        "symbol": "SREBF1",
        "hgnc": "HGNC:11289",
        "name": "sterol regulatory element binding transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srebf1"
      },
      {
        "slug": "elane",
        "symbol": "ELANE",
        "hgnc": "HGNC:3309",
        "name": "elastase, neutrophil expressed",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elane"
      },
      {
        "slug": "nlrc4",
        "symbol": "NLRC4",
        "hgnc": "HGNC:16412",
        "name": "NLR family CARD domain containing 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nlrc4"
      }
    ]
  }
}