{
  "url": "https://dantelabs.com/traits/enlarged-epiphyses",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "enlarged-epiphyses",
    "id": "HP:0010580",
    "name": "Large end part of bone",
    "label": "Enlarged epiphyses",
    "definition": "Increased size of epiphyses.",
    "synonyms": [
      "Large epiphyses",
      "Widened, distorted epiphyses"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-epiphysis-morphology",
        "name": "Abnormal shape of end part of bone",
        "url": "https://dantelabs.com/traits/abnormal-epiphysis-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "bulging-epiphyses",
        "name": "Bulging end part of bone",
        "genes": 5,
        "url": "https://dantelabs.com/traits/bulging-epiphyses"
      },
      {
        "slug": "enlargement-of-the-proximal-femoral-epiphysis",
        "name": "Enlarged end part of innermost thighbone",
        "genes": 2,
        "url": "https://dantelabs.com/traits/enlargement-of-the-proximal-femoral-epiphysis"
      },
      {
        "slug": "enlarged-epiphyses-of-the-phalanges-of-the-hand",
        "name": "Enlarged end part of finger bones",
        "genes": 1,
        "url": "https://dantelabs.com/traits/enlarged-epiphyses-of-the-phalanges-of-the-hand"
      }
    ],
    "genes": [
      {
        "slug": "cog4",
        "symbol": "COG4",
        "hgnc": "HGNC:18620",
        "name": "component of oligomeric golgi complex 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog4"
      },
      {
        "slug": "ckap2l",
        "symbol": "CKAP2L",
        "hgnc": "HGNC:26877",
        "name": "cytoskeleton associated protein 2L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ckap2l"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "ccn6",
        "symbol": "CCN6",
        "hgnc": "HGNC:12771",
        "name": "cellular communication network factor 6",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ccn6"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "nkx3-2",
        "symbol": "NKX3-2",
        "hgnc": "HGNC:951",
        "name": "NK3 homeobox 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx3-2"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3r1"
      }
    ]
  }
}