{
  "url": "https://dantelabs.com/traits/elevated-circulating-beta-ctx-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "elevated-circulating-beta-ctx-concentration",
    "id": "HP:0031425",
    "name": "Elevated circulating beta-CTX concentration",
    "definition": "The concentration of beta-CTX (= beta-C-terminal telopeptide, = beta-C-terminal telopeptide of type I collagen) in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Increased circulating beta-C-terminal telopeptide level",
      "Increased circulating beta-CrossLaps level",
      "Increased circulating beta-CTx level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-beta-ctx-concentration",
        "name": "Abnormal circulating beta-CTX concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-beta-ctx-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "hgnc": "HGNC:2037",
        "name": "claudin 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn16"
      },
      {
        "slug": "tmem38b",
        "symbol": "TMEM38B",
        "hgnc": "HGNC:25535",
        "name": "transmembrane protein 38B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem38b"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "slc34a3",
        "symbol": "SLC34A3",
        "hgnc": "HGNC:20305",
        "name": "solute carrier family 34 member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a3"
      }
    ]
  }
}