{
  "url": "https://dantelabs.com/traits/diffuse-palmoplantar-hyperkeratosis",
  "trait": {
    "bundleId": "2026.10.21-311f020e",
    "release": "2026-09-01",
    "slug": "diffuse-palmoplantar-hyperkeratosis",
    "id": "HP:0007447",
    "name": "Diffuse palmoplantar hyperkeratosis",
    "definition": "Diffuse abnormal thickening of the skin on the palms and soles.",
    "synonyms": [
      "Diffuse palmoplantar keratoderma",
      "Hyperkeratosis, diffuse palmoplantar"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "palmoplantar-hyperkeratosis",
        "name": "Thickening of the outer layer of the skin of the palms and soles",
        "url": "https://dantelabs.com/traits/palmoplantar-hyperkeratosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jup"
      },
      {
        "slug": "klhl24",
        "symbol": "KLHL24",
        "hgnc": "HGNC:25947",
        "name": "kelch like family member 24",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl24"
      },
      {
        "slug": "klk11",
        "symbol": "KLK11",
        "hgnc": "HGNC:6359",
        "name": "kallikrein related peptidase 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klk11"
      },
      {
        "slug": "aqp5",
        "symbol": "AQP5",
        "hgnc": "HGNC:638",
        "name": "aquaporin 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aqp5"
      },
      {
        "slug": "krt1",
        "symbol": "KRT1",
        "hgnc": "HGNC:6412",
        "name": "keratin 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt1"
      },
      {
        "slug": "snap29",
        "symbol": "SNAP29",
        "hgnc": "HGNC:11133",
        "name": "synaptosome associated protein 29",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snap29"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt9",
        "symbol": "KRT9",
        "hgnc": "HGNC:6447",
        "name": "keratin 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt9"
      },
      {
        "slug": "slurp1",
        "symbol": "SLURP1",
        "hgnc": "HGNC:18746",
        "name": "secreted LY6/PLAUR domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slurp1"
      },
      {
        "slug": "rhbdf2",
        "symbol": "RHBDF2",
        "hgnc": "HGNC:20788",
        "name": "rhomboid 5 homolog 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhbdf2"
      }
    ]
  }
}