{
  "url": "https://dantelabs.com/traits/communicating-hydrocephalus",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "communicating-hydrocephalus",
    "id": "HP:0001334",
    "name": "Communicating hydrocephalus",
    "definition": "A form of hydrocephalus in which there is no visible obstruction to the flow of the cerebrospinal fluid between the ventricles and subarachnoid space.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "hydrocephalus",
        "name": "Too much cerebrospinal fluid in the brain",
        "url": "https://dantelabs.com/traits/hydrocephalus"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "p4hb",
        "symbol": "P4HB",
        "hgnc": "HGNC:8548",
        "name": "prolyl 4-hydroxylase subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/p4hb"
      },
      {
        "slug": "trim71",
        "symbol": "TRIM71",
        "hgnc": "HGNC:32669",
        "name": "tripartite motif containing 71",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim71"
      },
      {
        "slug": "b4gat1",
        "symbol": "B4GAT1",
        "hgnc": "HGNC:15685",
        "name": "beta-1,4-glucuronyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4gat1"
      },
      {
        "slug": "cdca7",
        "symbol": "CDCA7",
        "hgnc": "HGNC:14628",
        "name": "cell division cycle associated 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdca7"
      },
      {
        "slug": "crtap",
        "symbol": "CRTAP",
        "hgnc": "HGNC:2379",
        "name": "cartilage associated protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crtap"
      },
      {
        "slug": "dlg5",
        "symbol": "DLG5",
        "hgnc": "HGNC:2904",
        "name": "discs large MAGUK scaffold protein 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlg5"
      },
      {
        "slug": "dnmt3b",
        "symbol": "DNMT3B",
        "hgnc": "HGNC:2979",
        "name": "DNA methyltransferase 3 beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3b"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "gcdh",
        "symbol": "GCDH",
        "hgnc": "HGNC:4189",
        "name": "glutaryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcdh"
      },
      {
        "slug": "hells",
        "symbol": "HELLS",
        "hgnc": "HGNC:4861",
        "name": "helicase, lymphoid specific",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hells"
      },
      {
        "slug": "herc1",
        "symbol": "HERC1",
        "hgnc": "HGNC:4867",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/herc1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "sec24d",
        "symbol": "SEC24D",
        "hgnc": "HGNC:10706",
        "name": "SEC24 homolog D, COPII component",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24d"
      },
      {
        "slug": "ski",
        "symbol": "SKI",
        "hgnc": "HGNC:10896",
        "name": "SKI proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ski"
      },
      {
        "slug": "uhrf1",
        "symbol": "UHRF1",
        "hgnc": "HGNC:12556",
        "name": "ubiquitin like with PHD and ring finger domains 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uhrf1"
      },
      {
        "slug": "zbtb24",
        "symbol": "ZBTB24",
        "hgnc": "HGNC:21143",
        "name": "zinc finger and BTB domain containing 24",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zbtb24"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "trnt1",
        "symbol": "TRNT1",
        "hgnc": "HGNC:17341",
        "name": "tRNA nucleotidyl transferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trnt1"
      },
      {
        "slug": "trpv6",
        "symbol": "TRPV6",
        "hgnc": "HGNC:14006",
        "name": "transient receptor potential cation channel subfamily V member 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv6"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "dnai1",
        "symbol": "DNAI1",
        "hgnc": "HGNC:2954",
        "name": "dynein axonemal intermediate chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai1"
      },
      {
        "slug": "mpdz",
        "symbol": "MPDZ",
        "hgnc": "HGNC:7208",
        "name": "multiple PDZ domain crumbs cell polarity complex component",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpdz"
      }
    ]
  }
}