{
  "url": "https://dantelabs.com/traits/central-hypothyroidism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "central-hypothyroidism",
    "id": "HP:0011787",
    "name": "Central hypothyroidism",
    "definition": "A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      }
    ],
    "narrower": [
      {
        "slug": "pituitary-hypothyroidism",
        "name": "Low thyroid gland function due to abnormal pituitary gland",
        "genes": 40,
        "url": "https://dantelabs.com/traits/pituitary-hypothyroidism"
      },
      {
        "slug": "hypothalamic-hypothyroidism",
        "name": "Hypothalamic hypothyroidism",
        "genes": 11,
        "url": "https://dantelabs.com/traits/hypothalamic-hypothyroidism"
      }
    ],
    "genes": [
      {
        "slug": "dmxl2",
        "symbol": "DMXL2",
        "hgnc": "HGNC:2938",
        "name": "Dmx like 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dmxl2"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "nin",
        "symbol": "NIN",
        "hgnc": "HGNC:14906",
        "name": "ninein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nin"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "robo1",
        "symbol": "ROBO1",
        "hgnc": "HGNC:10249",
        "name": "roundabout guidance receptor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo1"
      },
      {
        "slug": "sel1l",
        "symbol": "SEL1L",
        "hgnc": "HGNC:10717",
        "name": "SEL1L adaptor subunit of SYVN1 ubiquitin ligase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sel1l"
      },
      {
        "slug": "cpe",
        "symbol": "CPE",
        "hgnc": "HGNC:2303",
        "name": "carboxypeptidase E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpe"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "ndn",
        "symbol": "NDN",
        "hgnc": "HGNC:7675",
        "name": "necdin, MAGE family member",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/ndn"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "hgnc": "HGNC:29433",
        "name": "neurite extension and migration factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexmif"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "rpl10",
        "symbol": "RPL10",
        "hgnc": "HGNC:10298",
        "name": "ribosomal protein L10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl10"
      },
      {
        "slug": "snrpn",
        "symbol": "SNRPN",
        "hgnc": "HGNC:11164",
        "name": "small nuclear ribonucleoprotein polypeptide N",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/snrpn"
      },
      {
        "slug": "cdon",
        "symbol": "CDON",
        "hgnc": "HGNC:17104",
        "name": "cell adhesion associated, oncogene regulated",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/cdon"
      },
      {
        "slug": "cripto",
        "symbol": "CRIPTO",
        "hgnc": "HGNC:11701",
        "name": "cripto, EGF-CFC family member",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/cripto"
      },
      {
        "slug": "disp1",
        "symbol": "DISP1",
        "hgnc": "HGNC:19711",
        "name": "dispatched RND transporter family member 1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/disp1"
      },
      {
        "slug": "dll1",
        "symbol": "DLL1",
        "hgnc": "HGNC:2908",
        "name": "delta like canonical Notch ligand 1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/dll1"
      },
      {
        "slug": "eif2ak3",
        "symbol": "EIF2AK3",
        "hgnc": "HGNC:3255",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak3"
      },
      {
        "slug": "fgf8",
        "symbol": "FGF8",
        "hgnc": "HGNC:3686",
        "name": "fibroblast growth factor 8",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgf8"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "foxh1",
        "symbol": "FOXH1",
        "hgnc": "HGNC:3814",
        "name": "forkhead box H1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/foxh1"
      },
      {
        "slug": "gas1",
        "symbol": "GAS1",
        "hgnc": "HGNC:4165",
        "name": "growth arrest specific 1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/gas1"
      },
      {
        "slug": "gnaq",
        "symbol": "GNAQ",
        "hgnc": "HGNC:4390",
        "name": "G protein subunit alpha q",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnaq"
      },
      {
        "slug": "insr",
        "symbol": "INSR",
        "hgnc": "HGNC:6091",
        "name": "insulin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/insr"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "hgnc": "HGNC:7865",
        "name": "nodal growth differentiation factor",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/nodal"
      },
      {
        "slug": "plch1",
        "symbol": "PLCH1",
        "hgnc": "HGNC:29185",
        "name": "phospholipase C eta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plch1"
      },
      {
        "slug": "ptch1",
        "symbol": "PTCH1",
        "hgnc": "HGNC:9585",
        "name": "patched 1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/ptch1"
      },
      {
        "slug": "shh",
        "symbol": "SHH",
        "hgnc": "HGNC:10848",
        "name": "sonic hedgehog signaling molecule",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/shh"
      },
      {
        "slug": "sim1",
        "symbol": "SIM1",
        "hgnc": "HGNC:10882",
        "name": "SIM bHLH transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sim1"
      },
      {
        "slug": "six3",
        "symbol": "SIX3",
        "hgnc": "HGNC:10889",
        "name": "SIX homeobox 3",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/six3"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "stil",
        "symbol": "STIL",
        "hgnc": "HGNC:10879",
        "name": "STIL centriolar assembly protein",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/stil"
      },
      {
        "slug": "tgif1",
        "symbol": "TGIF1",
        "hgnc": "HGNC:11776",
        "name": "TGFB induced factor homeobox 1",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/tgif1"
      },
      {
        "slug": "zic2",
        "symbol": "ZIC2",
        "hgnc": "HGNC:12873",
        "name": "Zic family zinc finger 2",
        "frequency": "occasional",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/zic2"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "irs4",
        "symbol": "IRS4",
        "hgnc": "HGNC:6128",
        "name": "insulin receptor substrate 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irs4"
      },
      {
        "slug": "katnip",
        "symbol": "KATNIP",
        "hgnc": "HGNC:29068",
        "name": "katanin interacting protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/katnip"
      },
      {
        "slug": "tbl1x",
        "symbol": "TBL1X",
        "hgnc": "HGNC:11585",
        "name": "transducin beta like 1 X-linked",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1x"
      }
    ]
  }
}