{
  "url": "https://dantelabs.com/traits/broad-jaw",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "broad-jaw",
    "id": "HP:0012802",
    "name": "Broad jaw",
    "definition": "Bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective).",
    "synonyms": [
      "Broad lower face",
      "Wide jaw",
      "Broad mandible",
      "Wide mandible"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-mandible-morphology",
        "name": "Abnormality of the lower jaw bone",
        "url": "https://dantelabs.com/traits/abnormal-mandible-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "snip1",
        "symbol": "SNIP1",
        "hgnc": "HGNC:30587",
        "name": "Smad nuclear interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snip1"
      },
      {
        "slug": "ano5",
        "symbol": "ANO5",
        "hgnc": "HGNC:27337",
        "name": "anoctamin 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano5"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp5"
      },
      {
        "slug": "sh3bp2",
        "symbol": "SH3BP2",
        "hgnc": "HGNC:10825",
        "name": "SH3 domain binding protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3bp2"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      }
    ]
  }
}