{
  "url": "https://dantelabs.com/traits/atrophic-scars",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "atrophic-scars",
    "id": "HP:0001075",
    "name": "Sunken or indented skin due to damage",
    "label": "Atrophic scars",
    "definition": "Scars that form a depression compared to the level of the surrounding skin because of damage to the collagen, fat or other tissues below the skin.",
    "synonyms": [
      "Thin, atrophic scars"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "atypical-scarring-of-skin",
        "name": "Atypical scarring of skin",
        "url": "https://dantelabs.com/traits/atypical-scarring-of-skin"
      },
      {
        "slug": "dermal-atrophy",
        "name": "Skin degeneration",
        "url": "https://dantelabs.com/traits/dermal-atrophy"
      }
    ],
    "narrower": [
      {
        "slug": "cigarette-paper-scars",
        "name": "Cigarette-paper scars",
        "genes": 10,
        "url": "https://dantelabs.com/traits/cigarette-paper-scars"
      },
      {
        "slug": "widened-atrophic-scar",
        "name": "Widened atrophic scar",
        "genes": 2,
        "url": "https://dantelabs.com/traits/widened-atrophic-scar"
      }
    ],
    "genes": [
      {
        "slug": "aebp1",
        "symbol": "AEBP1",
        "hgnc": "HGNC:303",
        "name": "AE binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aebp1"
      },
      {
        "slug": "col5a2",
        "symbol": "COL5A2",
        "hgnc": "HGNC:2210",
        "name": "collagen type V alpha 2 chain",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col5a2"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "obligate",
        "diseases": 10,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "dse",
        "symbol": "DSE",
        "hgnc": "HGNC:21144",
        "name": "dermatan sulfate epimerase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dse"
      },
      {
        "slug": "thbs2",
        "symbol": "THBS2",
        "hgnc": "HGNC:11786",
        "name": "thrombospondin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbs2"
      },
      {
        "slug": "chst14",
        "symbol": "CHST14",
        "hgnc": "HGNC:24464",
        "name": "carbohydrate sulfotransferase 14",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chst14"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "hgnc": "HGNC:2197",
        "name": "collagen type I alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col1a1"
      },
      {
        "slug": "col5a1",
        "symbol": "COL5A1",
        "hgnc": "HGNC:2209",
        "name": "collagen type V alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col5a1"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "lrp1",
        "symbol": "LRP1",
        "hgnc": "HGNC:6692",
        "name": "LDL receptor related protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp1"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "adamts2",
        "symbol": "ADAMTS2",
        "hgnc": "HGNC:218",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/adamts2"
      },
      {
        "slug": "adamtsl2",
        "symbol": "ADAMTSL2",
        "hgnc": "HGNC:14631",
        "name": "ADAMTS like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamtsl2"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "hgnc": "HGNC:930",
        "name": "beta-1,4-galactosyltransferase 7",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b4galt7"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "hgnc": "HGNC:1246",
        "name": "complement C1r",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/c1r"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "hgnc": "HGNC:1247",
        "name": "complement C1s",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1s"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "col1a2",
        "symbol": "COL1A2",
        "hgnc": "HGNC:2198",
        "name": "collagen type I alpha 2 chain",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/col1a2"
      },
      {
        "slug": "fkbp14",
        "symbol": "FKBP14",
        "hgnc": "HGNC:18625",
        "name": "FKBP prolyl isomerase 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp14"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "plod1",
        "symbol": "PLOD1",
        "hgnc": "HGNC:9081",
        "name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plod1"
      },
      {
        "slug": "plec",
        "symbol": "PLEC",
        "hgnc": "HGNC:9069",
        "name": "plectin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plec"
      },
      {
        "slug": "smad3",
        "symbol": "SMAD3",
        "hgnc": "HGNC:6769",
        "name": "SMAD family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad3"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "col3a1",
        "symbol": "COL3A1",
        "hgnc": "HGNC:2201",
        "name": "collagen type III alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col3a1"
      },
      {
        "slug": "itga6",
        "symbol": "ITGA6",
        "hgnc": "HGNC:6142",
        "name": "integrin subunit alpha 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga6"
      }
    ]
  }
}