{
  "url": "https://dantelabs.com/traits/ankylosis",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "ankylosis",
    "id": "HP:0031013",
    "name": "Ankylosis",
    "definition": "A reduction of joint mobility resulting from changes involving the articular surfaces.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "limitation-of-joint-mobility",
        "name": "Limitation of joint mobility",
        "url": "https://dantelabs.com/traits/limitation-of-joint-mobility"
      }
    ],
    "narrower": [
      {
        "slug": "elbow-ankylosis",
        "name": "Elbow ankylosis",
        "genes": 8,
        "url": "https://dantelabs.com/traits/elbow-ankylosis"
      },
      {
        "slug": "ankylosis-of-feet-small-joints",
        "name": "Ankylosis of feet small joints",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ankylosis-of-feet-small-joints"
      }
    ],
    "genes": [
      {
        "slug": "zmpste24",
        "symbol": "ZMPSTE24",
        "hgnc": "HGNC:12877",
        "name": "zinc metallopeptidase STE24",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmpste24"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "perp",
        "symbol": "PERP",
        "hgnc": "HGNC:17637",
        "name": "p53 apoptosis effector related to PMP22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/perp"
      },
      {
        "slug": "trpv3",
        "symbol": "TRPV3",
        "hgnc": "HGNC:18084",
        "name": "transient receptor potential cation channel subfamily V member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpv3"
      },
      {
        "slug": "adgrg6",
        "symbol": "ADGRG6",
        "hgnc": "HGNC:13841",
        "name": "adhesion G protein-coupled receptor G6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adgrg6"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "abcc6",
        "symbol": "ABCC6",
        "hgnc": "HGNC:57",
        "name": "ATP binding cassette subfamily C member 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc6"
      },
      {
        "slug": "enpp1",
        "symbol": "ENPP1",
        "hgnc": "HGNC:3356",
        "name": "ectonucleotide pyrophosphatase/phosphodiesterase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/enpp1"
      },
      {
        "slug": "gnai3",
        "symbol": "GNAI3",
        "hgnc": "HGNC:4387",
        "name": "G protein subunit alpha i3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnai3"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnas"
      }
    ]
  }
}