{
  "url": "https://dantelabs.com/traits/acanthocytosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acanthocytosis",
    "id": "HP:0001927",
    "name": "Acanthocytosis",
    "definition": "Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars.",
    "synonyms": [
      "Acanthocytes",
      "Red cell acanthocytosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "poikilocytosis",
        "name": "Poikilocytosis",
        "url": "https://dantelabs.com/traits/poikilocytosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "cad",
        "symbol": "CAD",
        "hgnc": "HGNC:1424",
        "name": "carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cad"
      },
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "sptb",
        "symbol": "SPTB",
        "hgnc": "HGNC:11274",
        "name": "spectrin beta, erythrocytic",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptb"
      },
      {
        "slug": "tor1a",
        "symbol": "TOR1A",
        "hgnc": "HGNC:3098",
        "name": "torsin family 1 member A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tor1a"
      },
      {
        "slug": "vps13a",
        "symbol": "VPS13A",
        "hgnc": "HGNC:1908",
        "name": "vacuolar protein sorting 13 homolog A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps13a"
      },
      {
        "slug": "xk",
        "symbol": "XK",
        "hgnc": "HGNC:12811",
        "name": "X-linked Kx blood group antigen, Kell and VPS13A binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xk"
      },
      {
        "slug": "mttp",
        "symbol": "MTTP",
        "hgnc": "HGNC:7467",
        "name": "microsomal triglyceride transfer protein",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mttp"
      },
      {
        "slug": "pank2",
        "symbol": "PANK2",
        "hgnc": "HGNC:15894",
        "name": "pantothenate kinase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pank2"
      },
      {
        "slug": "sar1b",
        "symbol": "SAR1B",
        "hgnc": "HGNC:10535",
        "name": "secretion associated Ras related GTPase 1B",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sar1b"
      },
      {
        "slug": "cyp4f22",
        "symbol": "CYP4F22",
        "hgnc": "HGNC:26820",
        "name": "cytochrome P450 family 4 subfamily F member 22",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp4f22"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      }
    ]
  }
}