{
  "url": "https://dantelabs.com/traits/absent-nipple",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "absent-nipple",
    "id": "HP:0002561",
    "name": "Absent nipple",
    "definition": "Congenital failure to develop, and absence of, the nipple.",
    "synonyms": [
      "Absent nipples",
      "Athelia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-breast",
        "name": "Abnormality of the breast",
        "url": "https://dantelabs.com/traits/abnormality-of-the-breast"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-nipples",
        "name": "Absent/small nipples",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-nipples"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ikzf2",
        "symbol": "IKZF2",
        "hgnc": "HGNC:13177",
        "name": "IKAROS family zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf2"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "ptprf",
        "symbol": "PTPRF",
        "hgnc": "HGNC:9670",
        "name": "protein tyrosine phosphatase receptor type F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprf"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "rspo2",
        "symbol": "RSPO2",
        "hgnc": "HGNC:28583",
        "name": "R-spondin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo2"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "cdh11",
        "symbol": "CDH11",
        "hgnc": "HGNC:1750",
        "name": "cadherin 11",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh11"
      },
      {
        "slug": "porcn",
        "symbol": "PORCN",
        "hgnc": "HGNC:17652",
        "name": "porcupine O-acyltransferase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/porcn"
      },
      {
        "slug": "eda",
        "symbol": "EDA",
        "hgnc": "HGNC:3157",
        "name": "ectodysplasin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eda"
      },
      {
        "slug": "slc25a24",
        "symbol": "SLC25A24",
        "hgnc": "HGNC:20662",
        "name": "solute carrier family 25 member 24",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a24"
      }
    ]
  }
}