{
  "url": "https://dantelabs.com/traits/abnormal-total-b-cell-count",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-total-b-cell-count",
    "id": "HP:0010975",
    "name": "Abnormal total B cell count",
    "definition": "The absolute number of B cells in the blood, per microlitre is outside the limits of normal of the reference range for the appropriate sex and age-group.",
    "synonyms": [
      "Abnormal B cell count",
      "Abnormal number of B cells",
      "Abnormal numbers of B cells",
      "Abnormality of B cell count",
      "Abnormality of B cell numbers"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-b-cell-morphology",
        "name": "Abnormal B cell morphology",
        "url": "https://dantelabs.com/traits/abnormal-b-cell-morphology"
      },
      {
        "slug": "abnormal-lymphocyte-count",
        "name": "Abnormal lymphocyte count",
        "url": "https://dantelabs.com/traits/abnormal-lymphocyte-count"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-total-b-cell-count",
        "name": "Low B cell count",
        "genes": 62,
        "url": "https://dantelabs.com/traits/decreased-total-b-cell-count"
      },
      {
        "slug": "increased-total-b-cell-count",
        "name": "Increased total B cell count",
        "genes": 12,
        "url": "https://dantelabs.com/traits/increased-total-b-cell-count"
      },
      {
        "slug": "absent-circulating-b-cells",
        "name": "Absent circulating B cells",
        "genes": 11,
        "url": "https://dantelabs.com/traits/absent-circulating-b-cells"
      }
    ],
    "genes": [
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      }
    ]
  }
}